ArticleFrontiers in aging neuroscience2020
Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Effectiveness of transcutaneous electrical nerve stimulation in improving cognitive function in older adults with cognitive impairment: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Verb fluency task in individuals with mild cognitive impairment and dementia: a scoping review.Dementia & neuropsychologia · 2026Review
- Detecting language network alterations in mild cognitive impairment using task-based fMRI and resting-state fMRI: A comparative study.Brain and behavior · 2024Article
- A curious case of retrogenesis in language: Automated analysis of language patterns observed in dementia patients and young children.Neuroscience informatics · 2024Article
- Objective and Subjective Clustering Methods for Verb Fluency Responses From Individuals With Alzheimer's Dementia and Cognitively Healthy Older Adults.American journal of speech-language pathology · 2023Article
- Diversity in verbal fluency performance and its associations with MRI-informed brain age matrices in normal ageing and neurocognitive disorders.CNS neuroscience & therapeutics · 2023Article
- Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults.International journal of molecular sciences · 2023Article
- Executive functioning and verbal fluency performance in youth with Down syndrome.Research in developmental disabilities · 2022Article
- Magnetoencephalography resting-state correlates of executive and language components of verbal fluency.Scientific reports · 2022Article
- Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer's disease.GeroScience · 2021Article
- fMRI Investigation of Semantic Lexical Processing in Healthy Control and Alzheimer's Disease Subjects Using Naming Task: A Preliminary Study.Brain sciences · 2021Article
- Emotional Valence Affects Word Retrieval During Verb Fluency Tasks in Alzheimer's Dementia.Frontiers in psychology · 2021Article
- Cognitive Functioning and Schizotypy: A Four-Years Study.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently there are ~6 million Americans who are affected by dementia. Verbal fluency tasks have been commonly and frequently utilized to document the disease progression in many forms of dementia. Verb fluency has been found to display substantial potential to detect and monitor the cognitive declines of individuals with dementia who have fronto-striatal involvement. The neural substrates underlying verb fluency task performance, however, have remained unclear so far, especially in individuals with dementia. Therefore, in the current study, brain activation patterns of seven individuals with dementia and nine healthy older adults were investigated using functional MRI. The participants performed in the scanner an overt, subject-paced verb fluency task, representative of fluency tasks used in clinical settings. The brain activation patterns during the verb fluency task were compared between the two groups, and a correlational analysis was conducted to determine the neural correlates of verb fluency performance. The results suggest that compared to healthy older adults, individuals with dementia demonstrated poorer verb fluency performance and showed higher activation in specific neural regions, such as the bilateral frontal lobe. In addition, the correlational analysis revealed that poorer verb fluency performance lead to increased activation in certain cortical and subcortical areas, including left hippocampus and right supramarginal gyrus. The current findings are consistent with previous neurophysiological findings related to semantic (noun) fluency performance in older adults and individuals with dementia and add to the empirical evidence that supports the role of the frontal lobe and hippocampus in verb retrieval and search. Declines in verb fluency performance cannot only be used as a cognitive marker, but also represent neuropathological changes due to the neurodegenerative disease.
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