Evidence map›Paper›PMID 32265667›Full record

ArticleFrontiers in cellular neuroscience2020

A Bright and Colorful Future for G-Protein Coupled Receptor Sensors.

Luca Ravotto, Loïc Duffet, Xuehan Zhou, Bruno Weber, Tommaso Patriarchi

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
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  5. Article
  6. P2XBritish journal of pharmacology · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Pharmacological Evaluation of Cannabinoid Receptor Modulators Using GRABInternational journal of molecular sciences · 2024
    Article
  11. Review
  12. Review
  13. Article
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  17. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luca RavottoInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Loïc DuffetInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Xuehan ZhouInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Bruno WeberInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
Tommaso PatriarchiInstitute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurochemicals have a large impact on brain states and animal behavior but are notoriously hard to detect accurately in the living brain. Recently developed genetically encoded sensors obtained from engineering a circularly permuted green fluorescent protein into G-protein coupled receptors (GPCR) provided a vital boost to neuroscience, by innovating the way we monitor neural communication. These new probes are becoming widely successful due to their flexible combination with state of the art optogenetic tools and

Indexed as

fluorescent proteinsgenetically encoded sensorsGPCRsin vivo imagingneuromodulatorsneurotransmitters

Identifiers

PMID32265667
PMCPMC7098945

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.