Evidence map›Paper›PMID 32265663›Full record

ArticleFrontiers in cellular neuroscience2020

PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury.

William Rodemer, Guixin Zhang, Isabelle Sinitsa, Jianli Hu, Li-Qing Jin, Shuxin Li, Michael E Selzer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

William RodemerShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Guixin ZhangShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Isabelle SinitsaShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Jianli HuShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Li-Qing JinShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Shuxin LiShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Michael E SelzerShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Temple University · US

Funding

Develop a combinatorial therapy for spinal cord injuryR01NS105961 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI LI, SHUXIN, ZOU, YIMIN · 2018 to 2022
$1.7M
CSPG receptors and PTEN in CNS regenerationR01NS079432 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI LI, SHUXIN · 2014 to 2018
$1.7M
CSPG-induced retrograde cell death and inhibition of regeneration after SCIR01NS092876 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI SELZER, MICHAEL EDGAR · 2016 to 2020
$1.7M
Therapeutic Strategies for Repairing Optic Nerve InjuryR01EY024575 · NEI · TEMPLE UNIV OF THE COMMONWEALTH · PI LI, SHUXIN · 2014 to 2017
$1.4M
NEI NIH HHS R01 EY024575NINDS NIH HHS R01 NS079432NINDS NIH HHS R01 NS092876NINDS NIH HHS R01 NS105961
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) results in persistent functional deficits due to the lack of axon regeneration within the mammalian CNS. After SCI, chondroitin sulfate proteoglycans (CSPGs) inhibit axon regrowth

Indexed as

cell deathCPSGSlampreysPTPRSregenerationspinal cord injury

Identifiers

PMID32265663
PMCPMC7096546
OpenAlexW3012417612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.