Evidence map›Paper›PMID 32265624›Full record

ArticleFrontiers in neuroscience2020

High-Frequency rTMS of the Motor Cortex Modulates Cerebellar and Widespread Activity as Revealed by SVM.

Jue Wang, Xin-Ping Deng, Yun-Ying Wu, Xiao-Long Li, Zi-Jian Feng, Hong-Xiao Wang, Ying Jing, Na Zhao, Yu-Feng Zang, Jian Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Combined repetitive transcranial magnetic stimulation and mirror therapy for upper limb rehabilitation in stroke survivors: A systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jue WangSchool of Psychology, Shanghai University of Sport, Shanghai, China.
Xin-Ping DengInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Yun-Ying WuInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Xiao-Long LiInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Zi-Jian FengInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Hong-Xiao WangInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Ying JingInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Na ZhaoInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Yu-Feng ZangInstitute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.
Jian ZhangSchool of Psychology, Shanghai University of Sport, Shanghai, China.
Affiliated Hospital of Hangzhou Normal University · CNHangzhou Normal University · CNShanghai University of Sport · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional magnetic resonance imaging (fMRI) studies have shown that the effect of repetitive transcranial magnetic stimulation (rTMS) can induce changes in remote brain regions. In the stimulated regions, low-frequency (≤1 Hz) rTMS induces inhibitory effects, while high-frequency (≥5 Hz) stimulation induces excitatory effects. However, these stereotypical effects arising from low- and high-frequency stimulation are based on measurements of motor evoked potentials (MEPs) induced by pulsed stimulation. To test the effects of rTMS on remote brain regions, the current study recruited 31 young healthy adults who participated in three rTMS sessions (10 Hz high frequency, 1 Hz low frequency, and sham) on three separate days. The stimulation target was based on individual fMRI activation in the motor cortex evoked by a finger movement task. Pre- and post-rTMS resting-state fMRI (RS-fMRI) were acquired. Regional homogeneity (ReHo) and degree centrality (DC) were calculated to measure the local and global connectivity, respectively. Compared with the sham session, high-frequency (10 Hz) rTMS significantly increased ReHo and DC in the right cerebellum, while low-frequency (1 Hz) stimulation did not significantly alter ReHo or DC. Then, using a newly developed PAIR support vector machine (SVM) method, we achieved accuracy of 93.18-97.24% by split-half validation for pairwise comparisons between conditions for ReHo or DC. While the univariate analyses suggest that high-frequency rTMS of the left motor cortex could affect distant brain activity in the right cerebellum, the multivariate SVM results suggest that both high- and low-frequency rTMS significantly modulated widespread brain activity. The current findings are useful for increasing the understanding of the mechanisms of rTMS, as well as guiding precise individualized rTMS treatment of movement disorders.

Indexed as

cerebellumfMRI-guided navigationmotor cortexresting-state fMRIrTMS

Identifiers

PMID32265624
PMCPMC7096733
OpenAlexW3012348857

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.