ArticleCommunications biology2020
Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Parallel expansion of trehalose transporter genes integrates intestinal energy metabolism with developmental growth in lepidopteran insects.Molecular biology and evolution · 2026Article
- A Drosophila tumor model identifies a conserved Upd-JAK/STAT-Akh signaling axis associated with metabolic changes in cancer cachexia.Disease models & mechanisms · 2026Article
- Evolutionary Analysis of Trehalose Breakdown Pathways.Genome biology and evolution · 2026Article
- Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation ineLife · 2026Article
- Genome-wide screen for deficiencies modifying Cyclin G-induced developmental instability in Drosophila melanogaster.Genetics · 2026Article
- Mechanistic insights in the role of trehalose transporter in metabolic homeostasis in response to dietary trehalose.G3 (Bethesda, Md.) · 2026Article
- Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels.Nature communications · 2026Article
- Tumour-host interactions in Drosophila: mechanisms in the tumour micro- and macroenvironment.Molecular oncology · 2026Review
- Trehalose metabolism: an integrative hub linking energy homeostasis and development in insects.Frontiers in insect science · 2026Review
- Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.Nature communications · 2025Article
- Trehalose supports the growth of Aedes aegypti cells and modifies gene expression and dengue virus type 2 replication.PLoS pathogens · 2025Article
- Glucose and trehalose metabolism through the cyclic pentose phosphate pathway shapes pathogen resistance and host protection in Drosophila.PLoS biology · 2024Article
- Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in matedScience advances · 2023Article
- Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model.Molecules (Basel, Switzerland) · 2023Article
- Drosophila suzukii energetic pathways are differently modulated by nutritional geometry in males and females.Scientific reports · 2022Article
- An improved organ explant culture method reveals stem cell lineage dynamics in the adulteLife · 2022Article
- The polyol pathway is an evolutionarily conserved system for sensing glucose uptake.PLoS biology · 2022Article
- Roles of Insect Oenocytes in Physiology and Their Relevance to Human Metabolic Diseases.Frontiers in insect science · 2022Review
- Differential Dose- and Tissue-Dependent Effects of foxo on Aging, Metabolic and Proteostatic Pathways.Cells · 2021Article
- Mild Muscle Mitochondrial Fusion Distress ExtendsInternational journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organisms have evolved molecular mechanisms to ensure consistent and invariant phenotypes in the face of environmental fluctuations. Developmental homeostasis is determined by two factors: robustness, which buffers against environmental variations; and developmental stability, which buffers against intrinsic random variations. However, our understanding of these noise-buffering mechanisms remains incomplete. Here, we showed that appropriate glycemic control confers developmental homeostasis in the fruit fly Drosophila. We found that circulating glucose levels are buffered by trehalose metabolism, which acts as a glucose sink in circulation. Furthermore, mutations in trehalose synthesis enzyme (Tps1) increased the among-individual and within-individual variations in wing size. Whereas wild-type flies were largely resistant to changes in dietary carbohydrate and protein levels, Tps1 mutants experienced significant disruptions in developmental homeostasis in response to dietary stress. These results demonstrate that glucose homeostasis against dietary stress is crucial for developmental homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.