ArticleScientific reports2020
Antimicrobial Resistance and Molecular Epidemiology of Staphylococcus aureus Causing Bloodstream Infections at Ruijin Hospital in Shanghai from 2013 to 2018.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mortality and genetic diversity of antibiotic-resistant bacteria associated with bloodstream infections: a systemic review and genomic analysis.BMC infectious diseases · 2024Pooled it
- Phylogenomic analysis of a methicillin-resistantMicrobial genomics · 2026Article
- Molecular Characterization of Clinical Isolates of Methicillin-ResistantPathogens (Basel, Switzerland) · 2025Article
- The characteristics of methicillin-resistantFrontiers in cellular and infection microbiology · 2025Article
- Genome-wide comparative analysis of CC1 Staphylococcus aureus between colonization and infection.European journal of medical research · 2024Article
- ST105 Lineage of MRSA: An Emerging Implication for Bloodstream Infection in the American and European Continents.Antibiotics (Basel, Switzerland) · 2024Review
- Genomic Characterization of Methicillin-Resistant and Methicillin-SusceptibleAntibiotics (Basel, Switzerland) · 2024Article
- Phylogenetic analysis and virulence characteristics of methicillin-resistantEmerging microbes & infections · 2023Article
- Molecular Characteristics and Prevalence of Rifampin Resistance inAntibiotics (Basel, Switzerland) · 2023Article
- Predictive models for sepsis in children with Staphylococcus aureus bloodstream infections: a retrospective cohort study.BMC pediatrics · 2023Article
- Prevalence of Multidrug-Resistant Bacteria in Healthcare-Associated Bloodstream Infections at Hospitals in Riyadh, Saudi Arabia.Pathogens (Basel, Switzerland) · 2023Article
- Emergence of microbial infections in some hospitals of Cairo, Egypt: studying their corresponding antimicrobial resistance profiles.BMC infectious diseases · 2023Article
- Phenotypic and genotypic characterization of linezolid resistance and the effect of antibiotic combinations on methicillin-resistant Staphylococcus aureus clinical isolates.Annals of clinical microbiology and antimicrobials · 2023Article
- Prevalence, antimicrobial resistance, and genetic characteristics ofCurrent research in food science · 2023Article
- A 10-year retrospective study of methicillin-resistantFrontiers in microbiology · 2023Article
- Identification of methicillin-resistantEmerging microbes & infections · 2022Article
- Methicillin-resistantEmerging microbes & infections · 2022Article
- High frequency of increased triclosan MIC among CC5 MRSA and risk of misclassification of the SCCmec into types.The Journal of antimicrobial chemotherapy · 2022Article
- Molecular Characteristics and Antibiotic Resistance ofPathogens (Basel, Switzerland) · 2022Article
- Mechanisms of high-level fosfomycin resistance in Staphylococcus aureus epidemic lineage ST5.The Journal of antimicrobial chemotherapy · 2022Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus or methicillin-resistant Staphylococcus aureus (MRSA) is an important issue associated with significant morbidity and mortality and well known as a predominant pathogen causing bloodstream infection (BSIs) globally. To estimate the antibiotic resistance and molecular characteristics of S. aureus causing BSIs in Shanghai, 120 S. aureus isolates (20 isolates each year) from the patients with S. aureus BSIs from 2013 to 2018 were randomly selected and enrolled in this study. Fifty-three (44.2%) MRSA isolates were determined, and no isolate was found resistant to vancomycin, daptomycin, synercid, linezolid and ceftaroline. The toxin genes tst, sec, seg and sei were found more frequently among MRSA isolates compared with MSSA isolates (all P < 0.0001). Twenty-nine sequence types (STs) were identified, and ST5 (23.3%) was the most common ST, followed by ST398 (11.7%) and ST764 (10.0%). SCCmec II (73.6%) was the most frequent SCCmec type among MRSA isolates. The dominant clonal complexes (CCs) were CC5 (ST5, ST764, ST965 and ST3066; 36.7%) and the livestock-associated clone CC398 (ST398, 11.7%). MRSA-CC5 was the predominant CC among MRSA isolates (37/53, 69.8%), and CC5-II MRSA was found in 34 isolates accounting for 91.9% (34/37) among CC5 MRSA isolates. In addition, all 29 tst-positive MRSA isolates were CC5-MRSA as well. Our study provided the properties and genotypes of S. aureus causing BSIs at Ruijin Hospital in Shanghai from 2013 to 2018, and might suggest of value clues for the further study insights into pathogenic mechanisms intrinsically referring to the development of human-adapted S. aureus clones and their diffusions.
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