ArticleScientific reports2020
Optimizing clozapine for chemogenetic neuromodulation of somatosensory cortex.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Glutamatergic pathway from deep layers of the insular cortex to the rostral central medial thalamic nucleus participates in neuropathic pain and anxiety-like behaviors in mice.The journal of headache and pain · 2026Article
- Novel rat model of gaming disorder: assessment of social reward and sex differences in behavior and c-Fos brain activity.Psychopharmacology · 2025Article
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- Breaking Through the Bottleneck: Krogh's Principle in Behavioral Neuroendocrinology and the Potential of Gene Editing.Integrative and comparative biology · 2023Review
- Clozapine-Induced Chemogenetic Neuromodulation Rescues Post-Stroke Deficits After Chronic Capsular Infarct.Translational stroke research · 2023Article
- Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction.PNAS nexus · 2023Article
- Chemogenetic modulation of the medial prefrontal cortex regulates resistance to acute stress-induced cognitive impairments.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.Science immunology · 2023Article
- Decreasing dorsal cochlear nucleus activity ameliorates noise-induced tinnitus perception in mice.BMC biology · 2022Article
- Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Review
- Article
- Translational PET applications for brain circuit mapping with transgenic neuromodulation tools.Pharmacology, biochemistry, and behavior · 2021Review
- Chemogenetics: drug-controlled gene therapies for neural circuit disorders.Cell & gene therapy insights · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clozapine (CLZ) has been proposed as an agonist for Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), to replace Clozapine-N-oxide (CNO); however, there are no reliable guidelines for the use of CLZ for chemogenetic neuromodulation. We titrated the optimal dose of CLZ required to evoke changes in neural activity whilst avoiding off-target effects. We also performed [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.