ArticleFemale pelvic medicine & reconstructive surgery2021
Cultivable Bacteria in Urine of Women With Interstitial Cystitis: (Not) What We Expected.
Article in Female pelvic medicine & reconstructive surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Genomic relatedness and clinical significance ofMicrobial genomics · 2021Trial
- The urinary microbiome, overactive bladder and bladder pain syndrome/interstitial cystitis - mechanisms, diagnostics and therapeutic opportunities.Nature reviews. Urology · 2026Review
- Outcomes of Long-Term Antibiotic Therapy in Women with Chronic Recalcitrant Cystitis.International urogynecology journal · 2026Article
- Strain-level heterogeneity in Gardnerella urinary tract persistence and pathogenesis in an in vivo model is consistent with comparative phylogenomic analyses.BMC microbiology · 2026Article
- Strain-level differences inbioRxiv : the preprint server for biology · 2025Article
- Genome sequences for nineMicrobiology resource announcements · 2025Article
- Pathogenic effects ofCurrent research in microbial sciences · 2025Article
- Therapeutic Approaches for Urologic Chronic Pelvic Pain Syndrome; Management: Research Advances, Experimental Targets, and Future Directions.The Journal of pharmacology and experimental therapeutics · 2024Review
- The Role of the Urobiome in Kidney Transplantation: A Systematic Review.Transplantation direct · 2024Article
- Survey of the infant male urobiome and genomic analysis of Actinotignum spp.NPJ biofilms and microbiomes · 2023Article
- Urinary Microbiome in Bladder Diseases-Review.Biomedicines · 2023Review
- Detection of Bacteria in Bladder Mucosa of Adult Females.The Journal of urology · 2023Article
- Microbiome in urological diseases: Axis crosstalk and bladder disorders.Investigative and clinical urology · 2023Review
- Clinical relevance of expanded quantitative urine culture in health and disease.Frontiers in cellular and infection microbiology · 2023Review
- Urinary Microbiome of Reproductive-Age Asymptomatic European Women.Microbiology spectrum · 2022Article
- The healthy urinary microbiome in asymptomatic participants in the MAPP Network Study: Relation to gender, age, and menopausal status.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Bladder Microbiome in the Context of Urological Disorders-Is There a Biomarker Potential for Interstitial Cystitis?Diagnostics (Basel, Switzerland) · 2022Review
- The Urobiomes of Adult Women With Various Lower Urinary Tract Symptoms Status Differ: A Re-Analysis.Frontiers in cellular and infection microbiology · 2022Article
- Article
- Genome Investigation of UrinarymSphere · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMultiple studies show cultivatable bacteria in urine of most women. The existence of these bacteria challenges interstitial cystitis (IC)/painful bladder syndrome (PBS) diagnosis, which presumes a sterile bladder. The aims of this study were (1) to compare the female bladder microbiomes in women with IC/PBS and unaffected controls and (2) to correlate baseline bladder microbiome composition with symptoms.
methodsThis cross-sectional study enrolled 49 IC/PBS and 40 controls. All provided catheterized urine samples and completed validated questionnaires. A subset of the IC/PBS cohort provided voided and catheterized urine samples. All samples from both cohorts were assessed by the expanded quantitative urine culture (EQUC) protocol; a subset was assessed by 16S rRNA gene sequencing.
resultsOf the IC/PBS cohort, 49.0% (24/49) were EQUC positive; in these EQUC-positive samples, the most common urotypes were Lactobacillus (45.8%) and Streptococcus (33.3%). Of the controls, 40.0% were EQUC positive; of these EQUC-positive samples, the most common urotype was Lactobacillus (50.0%). The urotype distribution was significantly different (P < 0.05), as 16% of the IC/PBS cohort, but 0% of controls, were Streptococcus urotype (P < 0.01). Symptom-free IC/PBS participants were less likely to be EQUC positive (12.5%) than IC/PBS participants with moderate or severe symptoms (68.8% and 46.2%) and the control cohort (60%; P < 0.05).
conclusionLactobacillus was the most common urotype. However, the presence of Lactobacillus did not differ between cohorts, and it did not impact IC/PBS symptom severity. Bacteria were not isolated from most participants with active IC/PBS symptoms. These findings suggest that bacteria may not be an etiology for IC/PBS.
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