Evidence map›Paper›PMID 32265336›Full record

ArticlemBio2020

Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human Gut

Guillaume Déjean, Kazune Tamura, Adriana Cabrera, Namrata Jain, Nicholas A Pudlo, Gabriel Pereira, Alexander Holm Viborg, Filip Van Petegem, Eric C Martens, Harry Brumer

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. A Hadza-enrichedGut microbes reports · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Beneficial Effects ofMicroorganisms · 2025
    Article
  14. Genetic analysis of a β-1,3/1,4-glucan utilization gene cluster inBioscience of microbiota, food and health · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. The catabolic specialization of the marine bacteriumApplied and environmental microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Guillaume Déjean *Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Kazune Tamura *Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Adriana CabreraMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Namrata JainMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Nicholas A PudloDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Gabriel PereiraDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Alexander Holm ViborgMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Filip Van PetegemDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-2728-8537
Eric C MartensDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Harry BrumerMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada brumer@msl.ubc.ca.ORCID 0000-0002-0101-862X
University of British Columbia · CAUniversity of Michigan · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Low dietary fiber and gut microbiota-induced mucus layer erosion as IBD triggersR01DK118024 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRACE Y. CHEN, Eric C Martens · 2018 to 2026
$4.9M
NIDDK NIH HHS R01 DK118024NIGMS NIH HHS P41 GM103393
6 · The paper itself

Abstract

The human gut microbiota (HGM) has far-reaching impacts on human health and nutrition, which are fueled primarily by the metabolism of otherwise indigestible complex carbohydrates commonly known as dietary fiber. However, the molecular basis of the ability of individual taxa of the HGM to address specific dietary glycan structures remains largely unclear. In particular, the utilization of β(1,3)-glucans, which are widespread in the human diet as yeast, seaweed, and plant cell walls, had not previously been resolved. Through a systems-based approach, here we show that the symbiont

Indexed as

Dietary FiberBacterial ProteinsBacteroidesbeta-GlucansCarrier ProteinsCell MembraneCohort StudiesCrystallography, X-RayGastrointestinal MicrobiomeGastrointestinal TractGlycoside HydrolasesHumansSubstrate SpecificityBacterial Proteinsbeta-GlucansCarrier ProteinsDietary FiberGlycoside HydrolasesBacteroidesBacteroidetesdietary fiberglycan-binding proteinglycoside hydrolasepolysaccharidespolysaccharide utilization locus

Identifiers

PMID32265336
PMCPMC7157763
OpenAlexW3014365043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.