Evidence map›Paper›PMID 32265333›Full record

ArticlemBio2020

Metabolism of Gluconeogenic Substrates by an Intracellular Fungal Pathogen Circumvents Nutritional Limitations within Macrophages.

Qian Shen, Stephanie C Ray, Heather M Evans, George S Deepe, Chad A Rappleye

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Tools for genetic manipulation of the endemic fungal pathogen,bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Review
  9. bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Extracellular niche establishment by plant pathogens.Nature reviews. Microbiology · 2024
    Review
  15. mBio · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Qian ShenDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Stephanie C RayDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Heather M EvansDivision of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
George S DeepeDivision of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Chad A RappleyeDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA rappleye.1@osu.edu.
The Ohio State University · USUniversity of Cincinnati Medical Center · US

Funding

GM-CSF-Induced Metal Sequestration and HistoplasmaR01AI106269 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2013 to 2022
$5.0M
Intracellular Proliferation of the fungal pathogen Histoplasma capsulatumR01AI148561 · NIAID · OHIO STATE UNIVERSITY · PI Chad A Rappleye · 2020 to 2026
$2.5M
HIF Regulation of Histoplasma PathogenesisR01AI133797 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2018 to 2022
$2.0M
Interdisciplinary Program in Microbe-Host BiologyT32AI112542 · NIAID · OHIO STATE UNIVERSITY · PI JUSTICE, SHERYL S, WOZNIAK, DANIEL J · 2014 to 2018
$644k
Forward genetics-based discovery of Histoplasma virulence genesR03AI111015 · NIAID · OHIO STATE UNIVERSITY · PI RAPPLEYE, CHAD A · 2014 to 2015
$147k
NIAID NIH HHS R01 AI106269NIAID NIH HHS R01 AI133797NIAID NIH HHS R01 AI148561NIAID NIH HHS R03 AI111015NIAID NIH HHS T32 AI112542
6 · The paper itself

Abstract

Microbial pathogens exploit host nutrients to proliferate and cause disease. Intracellular pathogens, particularly those exclusively living in the phagosome such as

Indexed as

GluconeogenesisMetabolic Networks and PathwaysAnimalsCell LineFungal ProteinsGene Expression ProfilingGlycolysisHistoplasmaHistoplasmosisLungMacrophagesMetabolomicsMiceMice, Inbred C57BLPhagosomesVirulenceFungal Proteinscarbon metabolismHistoplasmaintracellular pathogensmacrophagespathogenesisphagosomesvirulence

Identifiers

PMID32265333
PMCPMC7157778
OpenAlexW3014672351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.