Evidence map›Paper›PMID 32265330›Full record

ArticlemBio2020

RhlR-Regulated Acyl-Homoserine Lactone Quorum Sensing in a Cystic Fibrosis Isolate of Pseudomonas aeruginosa.

Renae L Cruz, Kyle L Asfahl, Sara Van den Bossche, Tom Coenye, Aurélie Crabbé, Ajai A Dandekar

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. mSphere · 2026
    Article
  3. ClpP2 modulates ClpXP assembly to promote multiple pathogenic phenotypes inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Modulation of themBio · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Quorum Sensing and its Inhibition inCurrent drug targets · 2025
    Review
  17. Article
  18. Review
  19. Review
  20. The relationship betweenJournal of bacteriology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Renae L CruzDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Kyle L AsfahlDepartment of Medicine, University of Washington, Seattle, Washington, USA.ORCID 0000-0001-5626-3529
Sara Van den BosscheLaboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.ORCID 0000-0001-7839-8758
Tom CoenyeLaboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.ORCID 0000-0002-6407-0601
Aurélie CrabbéLaboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.ORCID 0000-0003-3084-4418
Ajai A DandekarDepartment of Microbiology, University of Washington, Seattle, Washington, USA dandekar@u.washington.edu.ORCID 0000-0002-2992-6523
Ghent University · BEUniversity of Washington · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
RESPIRATORY RESEARCH TRAINING PROGRAMT32HL007287 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kristina Anne Crothers, David J. Horne · 1985 to 2026
$16.7M
Pseudomonas aeruginosa quorum sensingR01GM125714 · NIGMS · UNIVERSITY OF WASHINGTON · PI DANDEKAR, AJAI · 2018 to 2022
$1.6M
Doris Duke Charitable Foundation 2017073NHLBI NIH HHS T32 HL007287NIDDK NIH HHS P30 DK089507NIGMS NIH HHS R01 GM125714Wellcome Trust
6 · The paper itself

Abstract

The opportunistic pathogen

Indexed as

Gene Expression Regulation, BacterialA549 CellsBacterial ProteinsChildChild, PreschoolCystic FibrosisHumansPseudomonas aeruginosaPseudomonas InfectionsQuorum SensingVirulence FactorsBacterial ProteinsRhlR protein, Pseudomonas aeruginosaVirulence Factorschronic infectioncytotoxicityRhlRtranscriptome

Identifiers

PMID32265330
PMCPMC7157775
OpenAlexW3014777536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.