Evidence map›Paper›PMID 32265288›Full record

ArticleG3 (Bethesda, Md.)2020

A Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination in

Daniele Novarina, Ridhdhi Desai, Jessica A Vaisica, Jiongwen Ou, Mohammed Bellaoui, Grant W Brown, Michael Chang

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Daniele NovarinaEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands.
Ridhdhi DesaiDepartment of Biochemistry and Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Jessica A VaisicaDepartment of Biochemistry and Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.ORCID 0000-0001-5213-9344
Jiongwen OuDepartment of Biochemistry and Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Mohammed BellaouiDepartment of Biochemistry and Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Grant W BrownDepartment of Biochemistry and Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada grant.brown@utoronto.ca.ORCID 0000-0002-9002-5003
Michael ChangEuropean Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, the Netherlands.ORCID 0000-0002-1706-3337
University of Toronto · CAUniversity Medical Center Groningen · NL

Funding

CIHR FDN-159913CIHR MOP-79368
6 · The paper itself

Abstract

Homologous recombination is an important mechanism for genome integrity maintenance, and several homologous recombination genes are mutated in various cancers and cancer-prone syndromes. However, since in some cases homologous recombination can lead to mutagenic outcomes, this pathway must be tightly regulated, and mitotic hyper-recombination is a hallmark of genomic instability. We performed two screens in

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsDNA RepairHumansRecQ HelicasesRepetitive Sequences, Nucleic AcidDNA-Binding ProteinsRecQ HelicasesSaccharomyces cerevisiae ProteinsSGS1 protein, S cerevisiaeDirect repeatDNA damageDNA repairFunctional genomicsGenome stabilityHomologous recombinationSaccharomyces cerevisiae

Identifiers

PMID32265288
PMCPMC7263696
OpenAlexW3014437707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.