ArticleCancer research2020
Targeted Inhibition of the E3 Ligase SCF
Open access · greenAbstract read
In one paragraph
Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Integrating molecular subtypes, genomics and functional dependencies to identify context-specific therapeutic vulnerabilities in small cell lung cancer.Biomarker research · 2026Review
- A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2.Nature biotechnology · 2026Article
- Single-Cell RNA Analysis of Murine Osteosarcoma Uncovers Skp2 Function in Metastasis, Genomic Instability, and Immune Activation and Reveals Additional Target Pathways.Cancer research communications · 2026Article
- SKP2 in Cancer: From Molecular Regulation to Therapeutic Vulnerabilities and Translational Perspectives.Drug design, development and therapy · 2026Review
- The multifaceted role of E3 ubiquitin ligases in cancer metastasis: mechanisms, targets, and therapeutic implications.Essays in biochemistry · 2025Review
- A pan-cancer analysis revealedPrecision clinical medicine · 2025Article
- A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins.Cancers · 2025Review
- Review
- The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells.Cellular oncology (Dordrecht, Netherlands) · 2024Article
- Advances of E3 ligases in lung cancer.Biochemistry and biophysics reports · 2024Review
- Targeted inhibition of SCFOncogene · 2024Article
- SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.Molecular cancer therapeutics · 2024Article
- SKping cell cycle regulation: role of ubiquitin ligase SKP2 in hematological malignancies.Frontiers in oncology · 2024Review
- MYOD-SKP2 axis boosts tumorigenesis in fusion negative rhabdomyosarcoma by preventing differentiation through p57Nature communications · 2023Article
- Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis.World journal of gastroenterology · 2023Article
- Development and validation of a gene-based classification model for pN2 lung adenocarcinoma.Translational lung cancer research · 2023Article
- Interfering with the Ubiquitin-Mediated Regulation of Akt as a Strategy for Cancer Treatment.International journal of molecular sciences · 2023Review
- Small-molecule compounds inhibiting S-phase kinase-associated protein 2: A review.Frontiers in pharmacology · 2023Review
- Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition.British journal of cancer · 2022Review
- A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Hongling ZhaoDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.
Niloy J IqbalDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.ORCID 0000-0003-0367-2569
Vineeth SukrithanDepartment of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, New York.
Cari NicholasDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.
Yingjiao XueDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.
Cindy YuDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.
Joseph LockerDepartment of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Juntao ZouDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York.
Edward L SchwartzDepartment of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, New York. edward.schwartz@einsteinmed.org liang.zhu@einstein.yu.edu.
Liang ZhuDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York. edward.schwartz@einsteinmed.org liang.zhu@einstein.yu.edu.
Albert Einstein College of Medicine · USUniversity of Pittsburgh · US
Funding
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2MVulnerability of SCLC based on bi-allelic genetic inactivation of RB1 and TP53R01CA230032 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SCHWARTZ, EDWARD L, ZHAO, HONGLING · 2019 to 2024
$2.0MNCI NIH HHS P30 CA013330NCI NIH HHS R01 CA230032
Abstract
The
Indexed as
AnimalsCDC2-CDC28 KinasesFemaleHumansLung NeoplasmsMaleMiceMice, KnockoutMolecular Targeted TherapyRetinoblastoma Binding ProteinsRetinoblastoma ProteinSmall Cell Lung CarcinomaSmall Molecule LibrariesS-Phase Kinase-Associated ProteinsUbiquitin-Protein LigasesXenograft Model Antitumor AssaysCDC2-CDC28 KinasesCKS1B protein, humanCks1 protein, mouseRB1 protein, humanRb1 protein, mouseRetinoblastoma Binding ProteinsRetinoblastoma ProteinSmall Molecule LibrariesS-Phase Kinase-Associated ProteinsUbiquitin-Protein Ligases
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.