Evidence map›Paper›PMID 32265202›Full record

ArticleThe British journal of ophthalmology2020

Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease.

Lu Chen, Meizhou Liu, Zheng Zhang, Kun Qiao, Ting Huang, Miaohong Chen, Na Xin, Zuliang Huang, Lei Liu, Guoming Zhang and 1 more

Registry-linked trialOpen access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04456556 (Combined Endophthalmitis and Orbital Cellulitis in Patients With Novel Coronavirus Disease), which is not on this map. Cited by 185 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 10 pooled it
58.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04456556 completednot on this map

Combined Endophthalmitis and Orbital Cellulitis in Patients With Novel Coronavirus Disease (COVID-19)

TypeobservationalSponsorMinia UniversityRan2020 to 2020Enrolled5ConditionsEndophthalmitis and Orbital Cellulitis
3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 10 syntheses or guidelines pooled it, 381 citations in OpenAlex.

  1. Neurological and Head/Eyes/Ears/Nose/Throat Manifestations of COVID-19: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
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  8. Guideline
  9. COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic.Klinische Monatsblatter fur Augenheilkunde · 2020
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  11. Article
  12. Article
  13. Review
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  18. Ocular manifestations in COVID-19 infections: a case series.Annals of medicine and surgery (2012) · 2023
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  20. Article

125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lu Chen *Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.ORCID 0000-0003-1141-8288
Meizhou Liu *Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.
Zheng ZhangThe Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
Kun QiaoThe Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
Ting HuangThe Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
Miaohong ChenOphthalmology, Shenzhen Eye Hospital, Shenzhen, China.
Na XinOphthalmology, Shenzhen Eye Hospital, Shenzhen, China.
Zuliang HuangOphthalmology, Shenzhen Eye Hospital, Shenzhen, China.
Lei Liu *The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
Guoming Zhang *Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China zhang-guoming@163.com.
Jiantao Wang *Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.
He Eye Hospital · CNShenzhen Third People’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19). PARTICIPANT AND

methodsA 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. The ocular characteristics, presence of viral RNA and viral dynamics of SARS-CoV-2 in the conjunctival specimens were evaluated.

resultsSlit lamp examination showed bilateral acute follicular conjunctivitis. RT-PCR assay demonstrated the presence of viral RNA in conjunctival specimen 13 days after onset (cycle threshold value: 31). The conjunctival swab specimens remained positive for SARS-CoV-2 on 14 and 17 days after onset. On day 19, RT-PCR result was negative for SARS-CoV-2.

conclusionSARS-CoV-2 is capable of causing ocular complications such as viral conjunctivitis in the middle phase of illness. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. However, conjunctival sampling might not be useful for early diagnosis because the virus may not appear initially in the conjunctiva.

Indexed as

AdultAntiviral AgentsBetacoronavirusConjunctivitis, ViralCoronavirus InfectionsCOVID-19HumansMaleNasal CavityOphthalmic SolutionsPandemicsPharynxPneumonia, ViralRibavirinRNA, ViralSARS-CoV-2Antiviral AgentsOphthalmic SolutionsRibavirinRNA, Viralconjunctivainfection

Identifiers

PMID32265202
PMCPMC7211077
OpenAlexW3014611427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.