Evidence map›Paper›PMID 32265198›Full record

ArticleDevelopment (Cambridge, England)2020

Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance.

Trinidad M M Saez, Iván Fernandez Bessone, María S Rodriguez, Matías Alloatti, María G Otero, Lucas E Cromberg, Victorio M Pozo Devoto, Gonzalo Oubiña, Lucas Sosa, Mariano G Buffone and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Tau reduction with artificial microRNAs modulates neuronal physiology and improves tauopathy phenotypes in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Imaging the endocannabinoid signaling system.Journal of neuroscience methods · 2022
    Review
  15. Kinesins in Mammalian Spermatogenesis and Germ Cell Transport.Frontiers in cell and developmental biology · 2022
    Review
  16. The Giant Axon of the Squid: A Simple System for Axonal Transport Studies.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  17. In Vivo Live Imaging of Axonal Transport in Developing Zebrafish Axons.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  18. Review
  19. Review
  20. Review of the Endocannabinoid System.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Trinidad M M SaezInstituto de Biología Celular y Neurociencia, IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, CP 1121 Buenos Aires, Argentina tfalzone@fmed.uba.ar tsaez@fmed.uba.ar.ORCID 0000-0003-2801-8096
Iván Fernandez BessoneInstituto de Biología Celular y Neurociencia, IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, CP 1121 Buenos Aires, Argentina.ORCID 0000-0002-4792-7415
María S RodriguezInstituto de Biología Celular y Neurociencia, IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, CP 1121 Buenos Aires, Argentina.ORCID 0000-0001-8004-6655
Matías AlloattiInstituto de Biología Celular y Neurociencia, IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, CP 1121 Buenos Aires, Argentina.
María G OteroInstituto de Biología Celular y Neurociencia, IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, CP 1121 Buenos Aires, Argentina.ORCID 0000-0001-6263-2466
Lucas E CrombergInstituto de Biología Celular y Neurociencia, IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, CP 1121 Buenos Aires, Argentina.
Victorio M Pozo DevotoInstituto de Biología Celular y Neurociencia, IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, CP 1121 Buenos Aires, Argentina.ORCID 0000-0003-2468-8236
Gonzalo OubiñaInstituto de Biología y Medicina Experimental, IBYME (CONICET), CP 1428 Buenos Aires, Argentina.
Lucas SosaDepartamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, CP 5000 Córdoba, Argentina.
Mariano G BuffoneInstituto de Biología y Medicina Experimental, IBYME (CONICET), CP 1428 Buenos Aires, Argentina.ORCID 0000-0002-7163-6482
Diego M GelmanInstituto de Biología y Medicina Experimental, IBYME (CONICET), CP 1428 Buenos Aires, Argentina.ORCID 0000-0002-3699-2131
Tomás L FalzoneInstituto de Biología Celular y Neurociencia, IBCN (UBA-CONICET), Facultad de Medicina, Universidad de Buenos Aires, CP 1121 Buenos Aires, Argentina tfalzone@fmed.uba.ar tsaez@fmed.uba.ar.ORCID 0000-0002-7984-1149
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversidad Nacional de Córdoba · AR

Funding

ROLE OF ACTIN CYTOSKELETON DURING MOUSE SPERM ACROSOMAL EXOCYTOSISR01TW008662 · FIC · FUND INST BIOL Y MED EXPERIMENTAL · PI BUFFONE, MARIANO G · 2012 to 2016
$262k
FIC NIH HHS R01 TW008662
6 · The paper itself

Abstract

Endocannabinoids (eCB) modulate growth cone dynamics and axonal pathfinding through the stimulation of cannabinoid type-1 receptors (CB1R), the function of which depends on their delivery and precise presentation at the growth cone surface. However, the mechanism involved in the axonal transport of CB1R and its transport role in eCB signaling remains elusive. As mutations in the kinesin-1 molecular motor have been identified in patients with abnormal cortical development and impaired white matter integrity, we studied the defects in axonal pathfinding and fasciculation in mice lacking the kinesin light chain 1 (

Indexed as

Axonal TransportAnimalsAxonsCannabinoidsCerebral CortexGene DeletionGrowth ConesKinesinsMice, Inbred C57BLProtein SubunitsReceptor, Cannabinoid, CB1ThalamusCannabinoidsKinesinsKns2 protein, mouseProtein SubunitsReceptor, Cannabinoid, CB1ActinAxonal growthAxonal pathfindingAxonal transportCannabinoidEndocannabinoidsKinesinTrafficking

Identifiers

PMID32265198
PMCPMC7188441
OpenAlexW3014658617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.