Evidence map›Paper›PMID 32264975›Full record

ArticleAlzheimer's research & therapy2020

Enhanced diagnostic accuracy for neurocognitive disorders: a revised cut-off approach for the Montreal Cognitive Assessment.

Alessandra E Thomann, Manfred Berres, Nicolai Goettel, Luzius A Steiner, Andreas U Monsch

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 139 citations in OpenAlex.

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  19. Immune-proteo-metabolomic changes link to Aβ and tau pathology in Alzheimer disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Alessandra E ThomannMemory Clinic, University Department of Geriatric Medicine FELIX PLATTER, Burgfelderstrasse 101, CH-4055, Basel, Switzerland.
Manfred BerresDepartment of Mathematics and Technology, University of Applied Sciences Koblenz, Koblenz, Germany.
Nicolai GoettelAnesthesiology, University Hospital Basel, Basel, Switzerland.
Luzius A SteinerAnesthesiology, University Hospital Basel, Basel, Switzerland.
Andreas U MonschMemory Clinic, University Department of Geriatric Medicine FELIX PLATTER, Burgfelderstrasse 101, CH-4055, Basel, Switzerland. andreas.monsch@felixplatter.ch.
Felix Platter-Hospital · CHUniversity Hospital of Basel · CHKoblenz University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Montreal Cognitive Assessment (MoCA) has good sensitivity for mild cognitive impairment, but specificity is low when the original cut-off (25/26) is used. We aim to revise the cut-off on the German MoCA for its use in clinical routine.

methodsData were analyzed from 496 Memory Clinic outpatients (447 individuals with a neurocognitive disorder; 49 with cognitive normal findings) and from 283 normal controls. Cut-offs were identified based on (a) Youden's index and (b) the 10th percentile of the control group.

resultsA cut-off of 23/24 on the MoCA had better correct classification rates than the MMSE and the original MoCA cut-off. Compared to the original MoCA cut-off, the cut-off of 23/24 points had higher specificity (92% vs 63%), but lower sensitivity (65% vs 86%). Introducing two separate cut-offs increased diagnostic accuracies with 92% specificity (23/24 points) and 91% sensitivity (26/27 points). Scores between these two cut-offs require further examinations.

conclusionsUsing two separate cut-offs for the MoCA combined with scores in an indecisive area enhances the accuracy of cognitive screening.

Indexed as

Cognitive DysfunctionDementiaMental Status and Dementia TestsFemaleHumansNeuropsychological TestsReproducibility of ResultsROC CurveSensitivity and SpecificityArea under curveCognitive dysfunctionMental status and dementia testsMini Mental State ExaminationMontreal Cognitive AssessmentNeurocognitive disordersNeuropsychologyROC curveSensitivity and specificity

Identifiers

PMID32264975
PMCPMC7140337
OpenAlexW3014449822

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.