Evidence map›Paper›PMID 32264938›Full record

ArticleClinical epigenetics2020

Differential CpG DNA methylation in peripheral naïve CD4

R Pitaksalee, A N Burska, S Ajaib, J Rogers, R Parmar, K Mydlova, X Xie, A Droop, J S Nijjar, P Chambers and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. [Role of Trained Immunity in the Association Between Periodontitis and Rheumatoid Arthritis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Observational
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

R PitaksaleeLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
A N BurskaLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
S AjaibLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
J RogersLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
R ParmarLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
K MydlovaLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
X XieLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
A DroopLeeds Institute for Data Analytics, University of Leeds, Leeds, UK.
J S NijjarInstitute of Infection Immunity and Inflammation, University of Glasgow, Glasgow, UK.
P ChambersLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
P EmeryLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
R HodgettLeeds University Business School, University of Leeds, Leeds, UK.
I B McInnesInstitute of Infection Immunity and Inflammation, University of Glasgow, Glasgow, UK.
F PonchelLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK. f.ponchel@leeds.ac.uk.
NIHR Leeds Musculoskeletal Biomedical Research Unit · GBUniversity of Leeds · GBUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genetic risk associated with rheumatoid arthritis (RA) includes genes regulating DNA methylation, one of the hallmarks of epigenetic re-programing, as well as many T-cell genes, with a strong MHC association, pointing to immunogenetic mechanisms as disease triggers leading to chronicity. The aim of our study was to explore DNA methylation in early, drug-naïve RA patients, towards a better understanding of early events in pathogenesis.

resultMonocytes, naïve and memory CD4

conclusionOur data provided novel conceptual advances in the understanding of early RA pathogenesis, with implications for early treatment and prevention.

Indexed as

DNA MethylationGene Regulatory NetworksArthritis, RheumatoidCase-Control StudiesCD4-Positive T-LymphocytesCpG IslandsFemaleHumansMaleMonocytesOligonucleotide Array Sequence AnalysisPromoter Regions, GeneticSequence Analysis, DNASignal TransductionTh17 CellsDNA methylationIllumina 450K arrayInterleukin-6Naïve CD4+ T-cellsRheumatoid arthritis

Identifiers

PMID32264938
PMCPMC7137446
OpenAlexW3014240243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.