ArticleBMC musculoskeletal disorders2020
Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly.
Article in BMC musculoskeletal disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
118 citing papers in PubMed, 5 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Influence of Resistance Training Variables to Improve Muscle Mass Outcomes in Sarcopenia: A Systematic Review With Meta-Regressions.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Enhancing Muscle Quality: Exploring Leucine and Whey Protein in Sarcopenic Individuals.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Prevalence and correlation of sarcopenia with Alzheimer's disease: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Pooled it
- Sarcopenia and blood albumin: A systematic review with meta-analysisBiomedica : revista del Instituto Nacional de Salud · 2021Pooled it
- Circulating Mediators of Apoptosis and Inflammation in Aging; Physical Exercise Intervention.International journal of environmental research and public health · 2021Trial
- Intervertebral disc degeneration is accelerated by GH overexpression but attenuated by GH antagonism.GeroScience · 2026Article
- Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nature reviews. Drug discovery · 2026Review
- Bioimpedance: From Body Composition Assessment to Emerging Technologies in Clinical Nutrition.Nutrients · 2026Review
- Treating age-related loss of muscle mass and function: Where should we be focusing?The Journal of physiology · 2026Review
- Restoration of circadian rhythm as novel targets against sarcopenia.Chinese medical journal · 2026Review
- Article
- The effects of anabolic-androgenic steroid use and training style on myogenic expression in trained male iron sport athletes.European journal of applied physiology · 2026Article
- A Cross-Sectional Analysis of Musculoskeletal and Functional Outcomes in Patients with Pituitary Disorders: Frailty and Sarcopenia.Journal of clinical medicine · 2026Article
- Research progress on the diagnosis and pathogenesis of chronic heart failure combined with sarcopenia.Journal of cardiothoracic surgery · 2026Review
- Using Interpretable Machine Learning with SHAP to Assess Dynapenic Abdominal Obesity as a Stroke Risk Predictor: A Prospective Cohort Study.Vascular health and risk management · 2026Article
- Chronic inflammation as a driving factor for sarcopenia: an update on pathophysiology and future therapeutic targets.Frontiers in pharmacology · 2026Review
- Malnutrition-Sarcopenia Syndrome in older adults: Causes, consequences, and countermeasures.EXCLI journal · 2026Review
- Inflammatory biomarkers and sarcopenia in older adults.Frontiers in aging · 2026Article
- Gender and Age-Related Decline in Lower Limb Standing Muscle Strength: Benchmarking for Rehabilitation Assessment.Sensors (Basel, Switzerland) · 2025Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAge-related sarcopenia is a serious global health issue in elderly individuals and for the community as it induces disability and significant economic burden. The purpose of the study is to understand the factors associated with sarcopenia and the role of growth hormone (GH) and insulin-like growth factor (IGF-1) in the occurrence of sarcopenia.
methodsElderly patients (n = 3276) were included in this cross-sectional study. Survey and measurement of body composition (bioelectrical impedance), grip strength, and step speed were performed according to the Asian Working Group on Sarcopenia (AWGS) diagnostic criteria. Hematological and hormonal indicators were compared between patients with and without sarcopenia in order to identify the associated factors.
resultsThere were significant differences in the demographic parameters between the sarcopenia and non-sarcopenia groups (all P < 0.05). There were significant differences between the two groups regarding the blood levels of GH, IGF-1, testosterone (T), and mechanical growth factor (MGF) (all P < 0.001). Correlation analyses showed that the appendicular skeletal muscle mass (ASMI) was positively associated with gender and BMI, and with GH, T, IGF-1, MGF, BUN, Cr, and Hb levels, but negatively associated with HDL-C (all P < 0.05). Logistic multivariable regression analysis showed that IGF-1, MGF, BMI, and gender were independently associated with appendicular skeletal muscle mass (ASMI) (all P < 0.05).
conclusionsGH and IGF-1 are associated with sarcopenia in the elderly. IGF-1 and MGF are independently associated with the reduction of skeletal muscle mass, along with BMI and gender.
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Registered trials
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