ArticleBMC pediatrics2020
Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort.
Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Guidelines on diagnosis and management of gastroesophageal reflux disease in infants, children and adolescents: a joint consensus from Italian pediatric societies (SIP and SIGENP) -Part II: management.Italian journal of pediatrics · 2026Guideline
- The Impact of Frenotomy on Gastroesophageal Reflux in Pediatric Ankyloglossia: A Systematic Review.The Annals of otology, rhinology, and laryngology · 2025Pooled it
- Guidelines on optimizing the use of proton pump inhibitors: PPI stewardship.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Guideline
- Wangshi Baochi Pill for functional dyspepsia syndrome in infants and toddlers: a multicenter randomized placebo-controlled trial.Translational pediatrics · 2026Article
- Integrating ultrasound biomechanics and clinical assessments to examine breastfeeding function: novel insights into tongue mobility, milk transfer, and reflux symptoms.International breastfeeding journal · 2026Article
- [Research progress and clinical practice considerations on assessment tools for gastroesophageal reflux disease in infants and young children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Aspiration pneumonia secondary to GERD (Sandifer syndrome) in a malnourished infant: a case report.Annals of medicine and surgery (2012) · 2026Article
- Infant Acid-Suppressant Medication, C. difficile Colonisation, and Childhood Body Mass Index in a Canadian Cohort.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Diagnosing milk aspiration as a cause of death in sudden unexpected infant death: forensic insights from post-mortem analysis impacting criminal investigations.Forensic science, medicine, and pathology · 2025Article
- Approach to the spectrum of infant non-IgE-mediated food allergy manifestations and physiologic infant behaviors.Current problems in pediatric and adolescent health care · 2025Review
- Association Between Dinner-to-Bed Time and Gastroesophageal Reflux-Related Diseases in Children.Cureus · 2025Article
- Age-dependent normal values for the 'Infant Gastroesophageal Reflux Questionnaire Revised'.European journal of pediatrics · 2024Article
- Change of Sleep Stage during Gastroesophageal Reflux in Infants.Children (Basel, Switzerland) · 2023Article
- Effectiveness of a starch thickened infant formula with reduced lactose content, probiotics and prebiotics on quality of life and clinical outcome in infants with regurgitation and/or colic.Frontiers in nutrition · 2023Article
- A Narrative Review on the Update in the Prevalence of Infantile Colic, Regurgitation, and Constipation in Young Children: Implications of the ROME IV Criteria.Frontiers in pediatrics · 2021Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastroesophageal reflux (GER) is common in infants. Gastroesophageal reflux disease (GERD) is defined as GER leading to troublesome symptoms that affect daily functioning and/or complications. This study is aimed at determining the prevalence and progression of GER and GERD in a cohort of healthy term infants from birth to 12 months old.
methodsWe conducted a prospective cohort study including all full-term living neonates born at Besançon Teaching Hospital, France. Parents completed a clinical report form and the Infant Gastroesophageal Reflux Questionnaire-Revised (I-GERQ-R) at 1, 3, 6, 10, and 12 months of age. GER was defined as score ≥ 1 to the first question with I-GERQ-R score < 16, and GERD as score ≥ 1 to the first question with I-GERQ-R score ≥ 16. Regurgitation was based on the answer to the first question of the I-GERQ-R as anything coming out of the mouth daily.
results157/347 births were included (83 boys). The prevalence of regurgitation at least once a day was 45.7% overall. In total: 72, 69, 56, 18, and 13% of infants regurgitated at least once a day at 1, 3, 6, 10, and 12 months of age, respectively. Physiological GER affected 53, 59, 51, 16, and 12% of infants; GERD, 19, 9, 5, 2, and 2%, respectively. Two risk factors were identified: family history of GER and exposure to passive smoking. Treatment included dietary modification (14%) and pharmacotherapy (5%).
conclusionPhysiological GER peaked at 3 months, GERD at 1 month. Most cases resolved on their own. GER and GERD are very common in the infant's population and parents should be reassured/educated regarding symptoms, warning signs, and generally favorable prognosis. I-GERQ-R is useful to the clinical screening and follow up for GER and GERD.
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