ArticleBMC ophthalmology2020
Endogenous Endophthalmitis: yield of the diagnostic evaluation.
Article in BMC ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Efficacy and safety of intraocular lens removal combined with vitrectomy for acute endophthalmitis in pseudophakic eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- A case report of ocular infection caused byAME case reports · 2026Article
- Endogenous endophthalmitis: a nine-year retrospective study of 33 patients.Eye (London, England) · 2026Article
- Article
- Clinical presentation and outcome of patients with endogenous endophthalmitis.International ophthalmology · 2025Article
- Retinal Detachment Complicating Endogenous Endophthalmitis in a COVID-19 Patient With SuperimposedCase reports in infectious diseases · 2025Article
- Infectious endophthalmitis associated with umbilical infection in Japanese black calf: a case report.Frontiers in veterinary science · 2025Article
- Rapid, multiplex and automated detection of bacteria and fungi in endophthalmitis via a microfluidic real-time pcr system.Journal of ophthalmic inflammation and infection · 2024Article
- Two-Decade Retrospective Analysis of Endogenous Endophthalmitis in Spain and Mexico: A Comprehensive Study.Journal of clinical medicine · 2024Article
- Clinical features, treatment and prognosis of patients with endogenous infectious endophthalmitis.International ophthalmology · 2024Review
- Endogenous Endophthalmitis Caused byTurkish journal of ophthalmology · 2024Article
- [Surgical therapy and pathogen detection in endogenous endophthalmitis : Analysis of data from five German eye hospitals].Die Ophthalmologie · 2024Article
- Study of clinical traits and systemic immune inflammation index assessments in patients with endogenous endophthalmitis over the last ten years.BMC ophthalmology · 2024Article
- Literature- and Experience-Based Consensus for Acute Post-operative Endophthalmitis and Endogenous Endophthalmitis in Taiwan.Ophthalmology and therapy · 2024Article
- Article
- Article
- Endogenous endophthalmitis in post-COVID-19 patients: a case report.Annals of medicine and surgery (2012) · 2023Article
- Pyogenic liver abscess complicated with endogenous endophthalmitis caused by Klebsiella pneumoniae: A case report and Literature Review.Immunity, inflammation and disease · 2023Review
- Gram-Negative Endogenous Endophthalmitis: A Systematic Review.Microorganisms · 2022Review
- Severe Retinal Necrosis Due to Klebsiella pneumoniae After Acute Prostatitis.The American journal of case reports · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndogenous endophthalmitis is an infection of the eye secondary to sepsis, occurring in 0.04-0.5% of bacteremia or fungemia. Risk factors include intravenous drug abuse (IVDA), diabetes, indwelling catheters, and immune suppression. Many patients have known or suspected bacteremia or fungemia; however, culture yield is reported to be low (approximately 50%). The purpose of this study is to elucidate the yield of diagnostic evaluation including microbial cultures over a 6.5 year period at an academic center in the United States.
methodsRetrospective chart review of patients with endogenous endophthalmitis at the University of Florida from June 2011 to February 2018.
resultsIncluded are 40 eyes of 35 patients. Endophthalmitis was secondary to an endogenous source in 23.5% of all endophthalmitis cases observed. Intraocular culture positivity was 28.6% overall but was 0% after initiation of systemic antibiotics. Most commonly identified organisms from the eye were coagulase-negative Staphylococcus and Candida. Blood culture positivity was 48.6%, most commonly Staphylococcus. IVDA was noted with increasing frequency as a risk factor. Diagnosis of endophthalmitis upon hospital admission was associated with a higher intraocular culture positivity (P = 0.040) and a shorter hospital stay (P = 0.035). Computed tomography (CT) and magnetic resonance imaging (MRI) were the highest yield imaging modalities; X-ray and non-ocular ultrasound were less diagnostically useful. Echocardiogram was positive by transesophageal route (TEE) in 22% and in 9% by transthoracic (TTE) testing. Following discharge from the hospital, 48.4% of patients failed to follow up with outpatient ophthalmology.
conclusionsBased on the results of this study, the interdisciplinary team should consider directed imaging, eye cultures prior to antimicrobial administration, thorough history for IVDA, and caution with premature discharge from the hospital.
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