ArticleBMC infectious diseases2020
Diagnosis of severe scrub typhus infection by next-generation sequencing:a case report.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Coronary artery lesions in pediatric scrub typhus: A case series from Guangzhou, China.PLoS neglected tropical diseases · 2026Article
- Scrub Typhus Presenting with Isolated Xerostomia.The American journal of tropical medicine and hygiene · 2026Article
- Severe paediatric scrub typhus with complications: a case report and literature review.BMC pediatrics · 2025Review
- Article
- Utility of next-generation sequencing for the etiological diagnosis ofInfectious medicine · 2024Article
- Case Report: Encephalitis with Initial Manifestation of Orientia Tsutsugamushi Infection Detected by Metagenomic Next-Generation Sequencing.Infection and drug resistance · 2024Article
- Clinical treatment of patients with scrub typhus-induced liver injury and intracranial infection.The Journal of international medical research · 2023Article
- Investigating the etiology of acute febrile illness: a prospective clinic-based study in Uganda.BMC infectious diseases · 2023Article
- Article
- Diagnosis of Coxiella burnetii infection via metagenomic next-generation sequencing: a case report.BMC infectious diseases · 2022Article
- The Early Diagnosis of Scrub Typhus by Metagenomic Next-Generation Sequencing.Frontiers in public health · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScrub typhus is an acute febrile illness, which was caused by Orientia tsutsugamushi and transmitted through the bite of chiggers. The diagnosis of scrub typhus could be missed diagnosis due to the absence of the pathognomonic eschar. CASE PRESENTATION: A 76-year-old man was hospitalized with fever and kidney injury and was diagnosed of hemorrhagic fever with renal syndrome first. However, the situation of the illness deteriorated into refractory septic shock and multiple organ dysfunction rapidly,although the treatment of anti-sepsis was used in 3rd-5th day. Orientia tsutsugamushi was determined to be the causative pathogen by Next-generation sequencing of his plasma sample in 6th day. Then, the patient was treated with doxycycline and azithromycin and recovered quickly.
conclusionsNext-generation sequencing was a new diagnostic technology and could identify scrub typhus in accurately and fast without the pathognomonic eschar.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.