ArticleTissue engineering. Part A2020
Effect of Ethylene Oxide Sterilization on Polyvinyl Alcohol Hydrogel Compared with Gamma Radiation.
Article in Tissue engineering. Part A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Review
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- Multifunctional Hydrogel-Based Scaffolds: Integrating Conductive Nanomaterials for Smart Wound Healing Applications.Gels (Basel, Switzerland) · 2026Review
- Biomimetic gradient hydrogels for osteochondral regeneration: from multi-dimensional design to clinical translation.Frontiers in bioengineering and biotechnology · 2026Review
- Biocompatible Stimuli-Sensitive Natural Hydrogels: Recent Advances in Biomedical Applications.Gels (Basel, Switzerland) · 2025Review
- The Effects of Biomimetic Surface Topography on Vascular Cells: Implications for Vascular Conduits.Advanced healthcare materials · 2024Review
- Tribomechanical Properties of PVA/NomexGels (Basel, Switzerland) · 2024Article
- Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts.Frontiers in drug delivery · 2024Article
- Autoclavable Albumin-Based Cryogels with Uncompromising Properties.Gels (Basel, Switzerland) · 2023Article
- Dynamic Stimulations with Bioengineered Extracellular Matrix-Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Article
- The effects of surface topography modification on hydrogel properties.APL bioengineering · 2021Review
- Fabrication and characterization of microstructure-controllable COL-HA-PVA hydrogels for cartilage repair.Journal of materials science. Materials in medicine · 2021Article
- Changing compliance of poly(vinyl alcohol) tubular scaffold for vascular graft applications through modifying interlayer adhesion and crosslinking density.Frontiers in materials · 2021Article
- Effect of sterilization treatment on mechanical properties, biodegradation, bioactivity and printability of GelMA hydrogels.Biomedical materials (Bristol, England) · 2020Article
- Fucoidan functionalization on poly(vinyl alcohol) hydrogels for improved endothelialization and hemocompatibility.Biomaterials · 2020Article
- Quantifying Physical Thrombus Characteristics on Cardiovascular Biomaterials Using MicroCT.Methods and protocols · 2020Article
- Regeneration of skeletal system with genipin crosslinked biomaterials.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
This study investigated the effects of terminal sterilization of polyvinyl alcohol (PVA) biomaterials using clinically translatable techniques, specifically ethylene oxide (EtO) and gamma (γ) irradiation. While a few studies have reported the possibility of sterilizing PVA with γ-radiation, the use of EtO sterilization of PVA requires additional study. PVA solutions were chemically crosslinked with trisodium trimetaphosphate and sodium hydroxide. The three experimental groups included untreated control, EtO, and γ-irradiation, which were tested for the degree of swelling and water content, and mechanical properties such as radial compliance, longitudinal tensile, minimum bend radius, burst pressure, and suture retention strength. In addition, samples were characterized with scanning electron microscopy, differential scanning calorimetry, X-ray photoelectron spectroscopy, and water contact angle measurements. Cell attachment was assessed using the endothelial cell line EA.hy926, and the sterilized PVA cytotoxicity was studied with a live/dead stain. Platelet and fibrin accumulation was measured using an
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.