Evidence map›Paper›PMID 32264748›Full record

ArticleEpigenetics2020

Major gene expression changes and epigenetic remodelling in Nile tilapia muscle after just one generation of domestication.

Ioannis Konstantinidis, Pål Sætrom, Robin Mjelle, Artem V Nedoluzhko, Diego Robledo, Jorge M O Fernandes

Abstract read
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
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  3. Skeletal Muscle Aging: Lessons From Teleosts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ioannis KonstantinidisFaculty of Biosciences and Aquaculture, Nord University , Bodø, Norway.ORCID 0000-0003-2560-5447
Pål SætromFaculty of Biosciences and Aquaculture, Nord University , Bodø, Norway.
Robin MjelleFaculty of Biosciences and Aquaculture, Nord University , Bodø, Norway.
Artem V NedoluzhkoFaculty of Biosciences and Aquaculture, Nord University , Bodø, Norway.ORCID 0000-0001-7040-0892
Diego RobledoThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh , Midlothian, UK.ORCID 0000-0002-9616-5912
Jorge M O FernandesFaculty of Biosciences and Aquaculture, Nord University , Bodø, Norway.ORCID 0000-0002-2550-1640

Funding

European Research Council 683210European Research Council 812986
6 · The paper itself

Abstract

The historically recent domestication of fishes has been essential to meet the protein demands of a growing human population. Selection for traits of interest during domestication is a complex process whose epigenetic basis is poorly understood. Cytosine hydroxymethylation is increasingly recognized as an important DNA modification involved in epigenetic regulation. In the present study, we investigated if hydroxymethylation plays a role in fish domestication and demonstrated for the first time at a genome-wide level and single nucleotide resolution that the muscle hydroxymethylome changes after a single generation of Nile tilapia (

Indexed as

DomesticationEpigenesis, Genetic5-MethylcytosineAnimalsDNA MethylationFish ProteinsMuscle, SkeletalSelective BreedingTilapia5-hydroxymethylcytosine5-MethylcytosineFish ProteinsDNA hydroxymethylationDomesticationepigeneticsmuscle growthOreochromis niloticus

Identifiers

PMID32264748
PMCPMC7116051

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.