Evidence map›Paper›PMID 32264739›Full record

ArticleVirulence2020

Molecularly defined extraintestinal pathogenic

Irene Merino, Stephen B Porter, Brian Johnston, Connie Clabots, Paul Thuras, Patricia Ruiz-Garbajosa, Rafael Cantón, James R Johnson

Open access · goldAbstract read
In one paragraph

Article in Virulence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mouse Models of Sepsis.Current protocols · 2024
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  6. Extended-spectrum beta-lactamase inOne health (Amsterdam, Netherlands) · 2023
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  15. Expansion of a Subset Within the C2 Subclade ofOpen forum infectious diseases · 2020
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Irene MerinoServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.ORCID 0000-0001-5841-7392
Stephen B PorterInfectious Diseases, Minneapolis Veterans Health Care System, Minneapolis, MN, USA.ORCID 0000-0002-9917-9295
Brian JohnstonMedicine, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-7347-9276
Connie ClabotsInfectious Diseases, Minneapolis Veterans Health Care System, Minneapolis, MN, USA.
Paul ThurasMental Health Service Line, Minneapolis Veterans Health Care System, Minneapolis, MN, USA.
Patricia Ruiz-GarbajosaServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.ORCID 0000-0003-4795-0217
Rafael CantónServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
James R JohnsonInfectious Diseases, Minneapolis Veterans Health Care System, Minneapolis, MN, USA.ORCID 0000-0002-9588-5045
Red Espanola de Investigacion en Patologia Infecciosa · ESUniversity of Minnesota · USMinneapolis VA Health Care System · US

Funding

Emergence of E. coli sequence type ST131I01CX000192 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI JOHNSON, JAMES R · 2009 to 2013
–
CSRD VA I01 CX000192CSRD VA I01 CX000920
6 · The paper itself

Abstract

backgroundMATERIALS AND

methodsWe tested in a murine sepsis model 84 ST131 isolates that differed by country of origin (Spain vs. USA), clonal subset, resistance markers, and virulence genes (VGs). Virulence outcomes, including illness severity score (ISS) and "killer" status (>80% mouse lethality), were compared statistically with clonal subset, individual and combined VGs, molecularly defined extraintestinal and uropathogenic

resultsVirulence varied widely by strain. Univariable correlates of median ISS and percent "killer" (outcomes if variable present vs. absent) included

conclusionWithin ST131 the strongest predictor of experimental virulence was molecularly defined ExPEC status. Clonal subsets seemed to behave differently in the murine sepsis model by country of origin.

Indexed as

AnimalsBacterial Typing Techniquesbeta-LactamasesDisease Models, AnimalDrug Resistance, Multiple, BacterialEscherichia coli InfectionsExtraintestinal Pathogenic Escherichia coliFemaleMiceMultilocus Sequence TypingSepsisSpainSpecific Pathogen-Free OrganismsUnited StatesVirulenceVirulence Factorsbeta-LactamasesVirulence FactorsE. coliExPECmouse sepsis modelvirulence

Identifiers

PMID32264739
PMCPMC7161687
OpenAlexW3014385383

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.