Evidence map›Paper›PMID 32264725›Full record

ReviewExpert review of respiratory medicine2020

Influences of environmental exposures on individuals living with cystic fibrosis.

Rhonda Szczesniak, Jessica L Rice, Cole Brokamp, Patrick Ryan, Teresa Pestian, Yizhao Ni, Eleni-Rosalina Andrinopoulou, Ruth H Keogh, Emrah Gecili, Rui Huang and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of respiratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Impact of Genetics on Endocrine Manifestations of Cystic Fibrosis.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. CFTR Modulators: From Mechanism to Targeted Therapeutics.Handbook of experimental pharmacology · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Clinical Phenotypes of Cystic Fibrosis Carriers.Annual review of medicine · 2022
    Review
  15. Article
  16. Review
  17. Association between phenotypic and genotypic characteristics and disease severity in individuals with cystic fibrosis.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022
    Article
  18. Association between insurance variability and early lung function in children with cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Observational
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Rhonda SzczesniakDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.
Jessica L RiceEudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Cole BrokampDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.
Patrick RyanDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.
Teresa PestianDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.
Yizhao NiDepartment of Pediatrics, University of Cincinnati , Cincinnati, OH, USA.
Eleni-Rosalina AndrinopoulouDepartment of Biostatistics, Erasmus Medical Center , Rotterdam, The Netherlands.
Ruth H KeoghDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine , London, UK.
Emrah GeciliDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.
Rui HuangDivision of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center , Cincinnati, OH, USA.
John P ClancyDepartment of Pediatrics, University of Cincinnati , Cincinnati, OH, USA.
Joseph M CollacoEudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · USJohns Hopkins Medicine · USCystic Fibrosis Foundation · USErasmus MC · NLLondon School of Hygiene & Tropical Medicine · GB

Funding

Multidisciplinary Training Program in Pediatric PulmonaryT32HL072748 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Joseph Michael Collaco · 2003 to 2026
$6.1M
R01- Mapping environmental contributions to rapid lung disease progression in cystic fibrosisR01HL141286 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SZCZESNIAK, RHONDA · 2019 to 2023
$2.3M
Gene-Environment Interactions in Cystic Fibrosis Lung DiseaseR01HL128475 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI COLLACO, JOSEPH MICHAEL · 2016 to 2019
$1.1M
Effect of Indoor Fine Particulate Matter Exposure on Respiratory Health Outcomes in Premature InfantsK23ES029985 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI RICE, JESSICA LYNNE · 2019 to 2022
$834k
Medical Research Council MR/S017968/1NHLBI NIH HHS R01 HL128475NHLBI NIH HHS R01 HL141286NHLBI NIH HHS T32 HL072748NIEHS NIH HHS K23 ES029985
6 · The paper itself

Abstract

introductionNatural, social, and constructed environments play a critical role in the development and exacerbation of respiratory diseases. However, less is known regarding the influence of these environmental/community risk factors on the health of individuals living with cystic fibrosis (CF), compared to other pulmonary disorders. AREAS COVERED: Here, we review current knowledge of environmental exposures related to CF, which suggests that environmental/community risk factors do interact with the respiratory tract to affect outcomes. Studies discussed in this review were identified in PubMed between March 2019 and March 2020. Although the limited data available do not suggest that avoiding potentially detrimental exposures other than secondhand smoke could improve outcomes, additional research incorporating novel markers of environmental exposures and community characteristics obtained at localized levels is needed. EXPERT OPINION: As we outline, some environmental exposures and community characteristics are modifiable; if not by the individual, then by policy. We recommend a variety of strategies to advance understanding of environmental influences on CF disease progression.

Indexed as

Cystic FibrosisAir PollutionEnvironmental ExposureHumansTobacco Smoke PollutionTobacco Smoke Pollutionair pollutionclimateCystic fibrosisenvironmentgeocodinggeographicgeomarkersecondhand smokesocioeconomic statusstressors

Identifiers

PMID32264725
PMCPMC7424635
OpenAlexW3014942502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.