ArticleJournal of materials chemistry. B2015
Biofabrication of reinforced 3D-scaffolds using two-component hydrogels.
Article in Journal of materials chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- Natural-Based Nanocomposite Ink Engineering for Seamless Multi-Material Integration in Extrusion-Based 3D Printing.Advanced healthcare materials · 2026Article
- Development and Characterization of Heparin-Containing Hydrogel/3D-Printed Scaffold Composites for Craniofacial Reconstruction.Annals of biomedical engineering · 2024Article
- Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructs.Biomacromolecules · 2024Article
- Review
- Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries.Bioactive materials · 2022Article
- Recent advances in melt electro writing for tissue engineering for 3D printing of microporous scaffolds for tissue engineering.Frontiers in bioengineering and biotechnology · 2022Review
- Use of liquid lithography to formJournal of micromechanics and microengineering : structures, devices, and systems · 2021Article
- The Importance of Interfaces in Multi-Material Biofabricated Tissue Structures.Advanced healthcare materials · 2021Review
- Polymers for Melt Electrowriting.Advanced healthcare materials · 2021Review
- Organoid Polymer Functionality and Mode ofAdvanced functional materials · 2020Article
- Bioprinting: From Tissue and Organ Development toChemical reviews · 2020Review
- Simultaneous Micropatterning of Fibrous Meshes and Bioinks for the Fabrication of Living Tissue Constructs.Advanced healthcare materials · 2019Article
- Article
- 3D printing of hydrogel composite systems: Recent advances in technology for tissue engineering.International journal of bioprinting · 2018Review
- Engineering Breast Cancer Microenvironments and 3D Bioprinting.Frontiers in bioengineering and biotechnology · 2018Review
- From intricate to integrated: Biofabrication of articulating joints.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Review
- Melt Electrospinning Writing of Poly-Hydroxymethylglycolide-co-ε-Caprolactone-Based Scaffolds for Cardiac Tissue Engineering.Advanced healthcare materials · 2017Article
- A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice.Nature communications · 2017Article
- Development of a thermosensitive HAMA-containing bio-ink for the fabrication of composite cartilage repair constructs.Biofabrication · 2017Article
- Recent advances in hydrogels for cartilage tissue engineering.European cells & materials · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Progress in biofabrication technologies is mainly hampered by the limited number of suitable hydrogels that can act as bioinks. Here, we present a new bioink for 3D-printing, capable of forming large, highly defined constructs. Hydrogel formulations consisted of a thermoresponsive polymer mixed with a poly(ethylene glycol) (PEG) or a hyaluronic acid (HA) cross-linker with a total polymer concentration of 11.3 and 9.1 wt% respectively. These polymer solutions were partially cross-linked before plotting by a chemoselective reaction called oxo-ester mediated native chemical ligation, yielding printable formulations. Deposition on a heated plate of 37 °C resulted in the stabilization of the construct due to the thermosensitive nature of the hydrogel. Subsequently, further chemical cross-linking of the hydrogel precursors proceeded after extrusion to form mechanically stable hydrogels that exhibited a storage modulus of 9 kPa after 3 hours. Flow and elastic properties of the polymer solutions and hydrogels were analyzed under similar conditions to those used during the 3D-printing process. These experiments showed the ability to extrude the hydrogels, as well as their rapid recovery after applied shear forces. Hydrogels were printed in grid-like structures, hollow cones and a model representing a femoral condyle, with a porosity of 48 ± 2%. Furthermore, an N-hydroxysuccinimide functionalized thermoplastic poly-ε-caprolactone (PCL) derivative was successfully synthesized and 3D-printed. We demonstrated that covalent grafting of the developed hydrogel to the thermoplastic reinforced network resulted in improved mechanical properties and yielded high construct integrity. Reinforced constructs also containing hyaluronic acid showed high cell viability of chondrocytes, underlining their potential for further use in regenerative medicine applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.