Evidence map›Paper›PMID 32260568›Full record

ArticleCancers2020

Stereotactic Radiotherapy for Ultra-Central Lung Oligometastases in Non-Small-Cell Lung Cancer.

Mauro Loi, Davide Franceschini, Luca Dominici, Ciro Franzese, Ilaria Chiola, Tiziana Comito, Marco Marzo, Giacomo Reggiori, Pietro Mancosu, Stefano Tomatis and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Tumor size as a key determinant of treatment strategy and prognosis in stereotactic body radiotherapy for pulmonary metastases: a retrospective study.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026
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  3. Lung metastases.Nature reviews. Disease primers · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Mauro LoiRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Davide FranceschiniRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Luca DominiciRadiotherapy Department, University of Florence, 50100 Florence, Italy.
Ciro FranzeseRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Ilaria ChiolaRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Tiziana ComitoRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Marco MarzoRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Giacomo ReggioriRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Pietro MancosuRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Stefano TomatisRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Joost NuyttensRadiotherapy Department, Erasmus MC Cancer Center, 3015GD Rotterdam, The Netherlands.
Marta ScorsettiRadiotherapy and Radiosurgery Department, Humanitas Cancer Center, 20089 Rozzano, Milan Area, Italy.
Humanitas University · ITErasmus MC Cancer Institute · NLUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStereotactic body radiotherapy (SBRT) in ultra-central (UC) lung tumors, defined in the presence of planning target volume (PTV) overlap or direct tumor abutment to the central bronchial tree or esophagus, may be correlated to a higher incidence of severe adverse events. Outcome and toxicity in oligometastatic (≤3 metastases) non-small-cell lung cancer (NSCLC) patients receiving SBRT for UC tumors were evaluated.

methodsOligometastatic NSCLC patients treated with SBRT for UC were retrospectively reviewed. Local control (LC), distant metastasis-free survival (DMFS), progression-free survival (PFS) and overall survival (OS) were calculated. Incidence and grade of toxicity were evaluated. Statistical analysis was performed to assess the impact of clinical and treatment-related variables on outcome and toxicity occurrence.

resultsSeventy-two patients were treated to a median biologically effective dose (BED) of 105 (75-132) Gy

conclusionsSBRT using dose-intensive schedules improves outcome in NSCLC patients. Overall toxicity is acceptable, although rare but potentially fatal toxicities may occur.

Indexed as

biologically effective dosenon-small-cell lung canceroligometastasesstereotactic radiotherapyultra-central

Identifiers

PMID32260568
PMCPMC7226119
OpenAlexW3014326477

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.