ArticleMicroorganisms2020
Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia.
Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- The Gut Microbiota and Diabetes: Research, Translation, and Clinical Applications-2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum.Diabetes care · 2024Review
- The gut microbiota and diabetes: research, translation, and clinical applications - 2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum.Diabetologia · 2024Review
- Delayed Gut Colonization Changes Future Insulin Resistance and Hepatic Gene Expression but Not Adiposity in Obese Mice.Journal of obesity · 2024Article
- Exploring the impact of diabetes on aging: insights from TERT and COL1A1 methylation.Turkish journal of biology = Turk biyoloji dergisi · 2024Article
- Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023Article
- Identifying potential therapeutic targets of mulberry leaf extract for the treatment of type 2 diabetes: a TMT-based quantitative proteomic analysis.BMC complementary medicine and therapies · 2023Article
- Exploring body weight-influencing gut microbiota by elucidating the association with diet and host gene expression.Scientific reports · 2023Article
- Gut Microbiota Restores Central Neuropeptide Deficits in Germ-Free Mice.International journal of molecular sciences · 2022Article
- The Metabolic Role and Therapeutic Potential of the Microbiome.Endocrine reviews · 2022Article
- Distribution and Difference of Gastrointestinal Flora in Sheep with Different Body Mass Index.Animals : an open access journal from MDPI · 2022Article
- More Active Intestinal Immunity Developed by Obese Mice Than Non-Obese Mice After Challenged byFrontiers in veterinary science · 2022Article
- Stevioside Attenuates Insulin Resistance in Skeletal Muscle by Facilitating IR/IRS-1/Akt/GLUT 4 Signaling Pathways: An In Vivo and In Silico Approach.Molecules (Basel, Switzerland) · 2021Article
- Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice.Molecular nutrition & food research · 2021Article
- Germ-free mice are not protected against diet-induced obesity and metabolic dysfunction.Acta physiologica (Oxford, England) · 2021Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. To test the hypothesis that Swiss Webster (Tac:SW) mice can develop characteristics of DIO and MetS in the absence of the IMB, we fed conventional (CV) and germ-free (GF) male Tac:SW mice either a low-fat diet (LFD; 10% fat derived calories) or a high-fat diet (HFD; 60% fat derived calories) for 10 weeks. The HFD increased feed conversion and body weight in GF mice independent of the increase associated with the microbiota in CV mice. In contrast to CV mice, GF mice did not decrease feed intake on the HFD and possessed heavier fat pads. The HFD caused hyperglycemia, hyperinsulinemia, and impaired glucose absorption in GF mice independent of the increase associated with the microbiota in CV mice. A HFD also elevated plasma LDL-cholesterol and increased hepatic triacylglycerol, free fatty acids, and ceramides in all mice, whereas hypertriglyceridemia and increased hepatic medium and long-chain acylcarnitines were only observed in CV mice. Therefore, GF male Tac:SW mice developed several detrimental effects of obesity and MetS from a high-fat, calorie dense diet.
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