ArticlePharmaceutics2020
Norfloxacin-Loaded Electrospun Scaffolds: Montmorillonite Nanocomposite vs. Free Drug.
Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Advancements in Chitosan-Based Scaffolds for Chondrogenic Differentiation and Knee Cartilage Regeneration: Current Trends and Future Perspectives.Bioengineering (Basel, Switzerland) · 2025Review
- Cerium Oxide and Chondroitin Sulfate Doped Polyurethane Scaffold to Bridge Tendons.ACS applied materials & interfaces · 2023Article
- Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields.Pharmaceutics · 2023Review
- Bentonite- and Palygorskite-Based Gels for Topical Drug Delivery Applications.Pharmaceutics · 2023Article
- Electrospun Scaffolds Based on Poly(butyl cyanoacrylate) for Tendon Tissue Engineering.International journal of molecular sciences · 2023Article
- Nanoclay-Doped Electrospun Nanofibers for Tissue Engineering: Investigation on the Structural Modifications in Physiological Environment.International journal of nanomedicine · 2023Article
- Effect of Organomontmorillonite-CloisitePharmaceutics · 2022Article
- Smart nano-in-microparticles to tackle bacterial infections in skin tissue engineering.Materials today. Bio · 2022Article
- Topographical and Compositional Gradient Tubular Scaffold for Bone to Tendon Interface Regeneration.Pharmaceutics · 2022Article
- Electrospun Nanofibers for Wound Management.ChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2022Article
- Functional Polymers as Innovative Tools in the Delivery of Antimicrobial Agents.Pharmaceutics · 2022Article
- Polysaccharide Electrospun Nanofibers for Wound Healing Applications.International journal of nanomedicine · 2022Review
- Advancement of Nanofibrous Mats and Common Useful Drug Delivery Applications.Advances in pharmacological and pharmaceutical sciences · 2022Review
- The Expanded Role of Chitosan in Localized Antimicrobial Therapy.Marine drugs · 2021Review
- Smart Device for Biologically Enhanced Functional Regeneration of Osteo-Tendon Interface.Pharmaceutics · 2021Article
- Biomaterials for Soft Tissue Repair and Regeneration: A Focus on Italian Research in the Field.Pharmaceutics · 2021Review
- Mixed Pluronic-Cremophor Polymeric Micelles as Nanocarriers for Poorly Soluble Antibiotics-The Influence on the Antibacterial Activity.Pharmaceutics · 2021Article
- Electrospun Scaffolds in Periodontal Wound Healing.Polymers · 2021Article
- Clay-Based Pharmaceutical Formulations and Drug Delivery Systems.Pharmaceutics · 2020Article
- Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic.Pharmaceutics · 2020Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Infections in nonhealing wounds remain one of the major challenges. Recently, nanomedicine approach seems a valid option to overcome the antibiotic resistance mechanisms. The aim of this study was the development of three types of polysaccharide-based scaffolds (chitosan-based (CH), chitosan/chondroitin sulfate-based (CH/CS), chitosan/hyaluronic acid-based (CH/HA)), as dermal substitutes, to be loaded with norfloxacin, intended for the treatment of infected wounds. The scaffolds have been loaded with norfloxacin as a free drug (N scaffolds) or in montmorillonite nanocomposite (H-hybrid-scaffolds). Chitosan/glycosaminoglycan (chondroitin sulfate or hyaluronic acid) scaffolds were prepared by means of electrospinning with a simple, one-step process. The scaffolds were characterized by 500 nm diameter fibers with homogeneous structures when norfloxacin was loaded as a free drug. On the contrary, the presence of nanocomposite caused a certain degree of surface roughness, with fibers having 1000 nm diameters. The presence of norfloxacin-montmorillonite nanocomposite (1%) caused higher deformability (90%-120%) and lower elasticity (5-10 mN/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.