Evidence map›Paper›PMID 32260364›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives.

Ayanda I Zulu, Ogunyemi O Oderinlo, Cuan Kruger, Michelle Isaacs, Heinrich C Hoppe, Vincent J Smith, Clinton G L Veale, Setshaba D Khanye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ayanda I ZuluDepartment of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa.ORCID 0000-0001-9036-5588
Ogunyemi O OderinloDepartment of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa.ORCID 0000-0002-6180-5502
Cuan KrugerDepartment of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa.
Michelle IsaacsCentre for Chemico and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa.
Heinrich C HoppeCentre for Chemico and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa.ORCID 0000-0003-4409-1955
Vincent J SmithDepartment of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa.ORCID 0000-0003-3546-3884
Clinton G L VealeSchool of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, South Africa.ORCID 0000-0002-4043-7106
Setshaba D KhanyeDepartment of Chemistry, Faculty of Science, Rhodes University, Grahamstown 6140, South Africa.ORCID 0000-0003-0725-5738
Rhodes University · ZA

Funding

South African National Research Foundation 107270
6 · The paper itself

Abstract

With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields. The resultant compounds were evaluated in vitro for their potential activity against a cultured

Indexed as

Cell ProliferationChalconesCrystallography, X-RayHeLa CellsHumansInhibitory Concentration 50Molecular StructurePyrrolesStructure-Activity RelationshipTrypanocidal AgentsTrypanosoma brucei bruceiChalconesPyrrolesTrypanocidal Agentsarylpyrrolechalconesmolecular hybridizationTrypanosoma bruceitrypanosomiasis

Identifiers

PMID32260364
PMCPMC7181280
OpenAlexW3014468149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.