Evidence map›Paper›PMID 32260357›Full record

ArticleInternational journal of molecular sciences2020

The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions.

Jörn Heuer, Franziska Heuer, René Stürmer, Sönke Harder, Hartmut Schlüter, Nayara Braga Emidio, Markus Muttenthaler, Dörthe Jechorek, Frank Meyer, Werner Hoffmann

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Jörn HeuerInstitute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
Franziska HeuerInstitute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
René StürmerInstitute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
Sönke HarderInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Hartmut SchlüterInstitute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.ORCID 0000-0002-9358-7036
Nayara Braga EmidioInstitute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID 0000-0001-7835-9636
Markus MuttenthalerInstitute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID 0000-0003-1996-4646
Dörthe JechorekInstitute of Pathology, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Frank MeyerDepartment of Surgery, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.
Werner HoffmannInstitute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.ORCID 0000-0003-0031-9540
Institute of Molecular Biology · DEOtto-von-Guericke-Universität Magdeburg · DEUniversität Hamburg · DEThe University of Queensland · AUUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TFF1 is a protective peptide of the Trefoil Factor Family (TFF), which is co-secreted with the mucin MUC5AC, gastrokine 2 (GKN2), and IgG Fc binding protein (FCGBP) from gastric surface mucous cells.

Indexed as

Carrier ProteinsCell Adhesion MoleculesCysteineGastric MucosaHumansMucin-6Protein BindingProtein MultimerizationPyloric AntrumTrefoil Factor-1Carrier ProteinsCell Adhesion MoleculesCysteineFCGBP protein, humanGKN2 protein, humanMUC6 protein, humanMucin-6TFF1 protein, humanTrefoil Factor-1FCGBPgastric cancergastric protectiongastrokineinflammationinnate immunitylectinmucinreactive oxygen speciestrefoil factor, TFF1

Identifiers

PMID32260357
PMCPMC7177788
OpenAlexW3014584745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.