Evidence map›Paper›PMID 32260204›Full record

ArticleMarine drugs2020

Secondary Metabolites from the Culture of the Marine-derived Fungus

Ambre Dezaire, Christophe H Marchand, Marine Vallet, Nathalie Ferrand, Soraya Chaouch, Elisabeth Mouray, Annette K Larsen, Michèle Sabbah, Stéphane D Lemaire, Soizic Prado and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Pharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ambre DezaireSorbonne Université, INSERM U938, Centre de Recherche Saint-Antoine, F-75012 Paris, France.
Christophe H MarchandCNRS, Sorbonne Université, Institut de Biologie Physico-Chimique, UMR8226, F-75005 Paris, France.
Marine ValletUnité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Muséum national d'Histoire naturelle, CNRS, F-75005 Paris, France.
Nathalie FerrandSorbonne Université, INSERM U938, Centre de Recherche Saint-Antoine, F-75012 Paris, France.
Soraya ChaouchUnité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Muséum national d'Histoire naturelle, CNRS, F-75005 Paris, France.
Elisabeth MourayUnité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Muséum national d'Histoire naturelle, CNRS, F-75005 Paris, France.
Annette K LarsenSorbonne Université, INSERM U938, Centre de Recherche Saint-Antoine, F-75012 Paris, France.
Michèle SabbahSorbonne Université, INSERM U938, Centre de Recherche Saint-Antoine, F-75012 Paris, France.
Stéphane D LemaireCNRS, Sorbonne Université, Institut de Biologie Physico-Chimique, UMR8226, F-75005 Paris, France.
Soizic PradoUnité Molécules de Communication et Adaptation des Micro-organismes (UMR 7245), Muséum national d'Histoire naturelle, CNRS, F-75005 Paris, France.
Alexandre E EscargueilSorbonne Université, INSERM U938, Centre de Recherche Saint-Antoine, F-75012 Paris, France.
Centre National de la Recherche Scientifique · FRInserm · FR

Funding

Agence Nationale de la Recherche ANR-11-EQPX-0008Agence Nationale de la Recherche ANR-LABX-011Institut Universitaire de Cancérologie, Sorbonne Université PhD program in OncologyMuseum Nationale Histoire Naturelle Action Transversale du Muséum "Biodiversité des Microorganismes dans les Ecosystèmes Actuels et Passés"
6 · The paper itself

Abstract

High-throughput screening assays have been designed to identify compounds capable of inhibiting phenotypes involved in cancer aggressiveness. However, most studies used commercially available chemical libraries. This prompted us to explore natural products isolated from marine-derived fungi as a new source of molecules. In this study, we established a chemical library from 99 strains corresponding to 45 molecular operational taxonomic units and evaluated their anticancer activity against the MCF7 epithelial cancer cell line and its invasive stem cell-like MCF7-Sh-WISP2 counterpart. We identified the marine fungal

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAntineoplastic AgentsAscomycotaBiological ProductsCell LineCell SurvivalFungiHumansMCF-7 CellsMiceMycotoxinsNeoplasmsPiperazinesSignal TransductionThioredoxin-Disulfide ReductaseAdaptor Proteins, Signal TransducingAKT1S1 protein, humanAntineoplastic AgentsBiological ProductshyalodendrinMycotoxinsPiperazinesThioredoxin-Disulfide ReductaseThioredoxinsTP53 protein, humanTumor Suppressor Protein p53anticancer agentepidithiodioxopiperazinesmarine-derived fungiresistant phenotypessecondary metabolites

Identifiers

PMID32260204
PMCPMC7230232
OpenAlexW3014768727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.