Evidence map›Paper›PMID 32260193›Full record

ArticleBrain sciences2020

Ex Vivo MRI Analytical Methods and Brain Pathology in Preterm Lambs Treated with Postnatal Dexamethasone

Nathanael J Yates, Kirk W Feindel, Andrew Mehnert, Richard Beare, Sophia Quick, Dominique Blache, J Jane Pillow, Rod W Hunt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Nathanael J YatesSchool of Human Sciences, University of Western Australia, Perth 6009, Australia.ORCID 0000-0003-2742-6952
Kirk W FeindelCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia.
Andrew MehnertCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia.
Richard BeareDevelopmental Imaging, Murdoch Children's Research Institute, Melbourne 3052, Australia.
Sophia QuickCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Perth 6009, Australia.
Dominique BlacheSchool of Agriculture and Environment, University of Western Australia, Perth 6009, Australia.ORCID 0000-0003-3476-3068
J Jane PillowSchool of Human Sciences, University of Western Australia, Perth 6009, Australia.
Rod W HuntMurdoch Children's Research Institute, Melbourne 3052, Australia.
The University of Western Australia · AUMurdoch Children's Research Institute · AUThe University of Melbourne · AUThe University of Queensland · AU

Funding

Cerebral Palsy Alliance Research Foundation Research FellowshipChiesi Farmaceutici Unrestricted donations were received for surfactant (poractant alfa)Fisher & Paykel Healthcare, NZ Ventilation circuitsICU Medical, Aust. Monitoring linesNational Health and Medical Research Council GNT1057514National Health and Medical Research Council GNT1057759National Health and Medical Research Council RF1077691Telethon Perth Children's Hospital Research Fund
6 · The paper itself

Abstract

Postnatal glucocorticoids such as dexamethasone are effective in promoting lung development in preterm infants, but are prescribed cautiously due to concerns of neurological harm. We developed an analysis pipeline for post-mortem magnetic resonance imaging (MRI) to assess brain development and hence the neurological safety profile of postnatal dexamethasone in preterm lambs. Lambs were delivered via caesarean section at 129 days' (d) gestation (full term ≈ 150 d) with saline-vehicle control (Saline,

Indexed as

animalsdexamethasoneglucocorticoidsinfantmagnetic resonance imagingneonatalneurodevelopmental disordersneurologyneuropathologypremature

Identifiers

PMID32260193
PMCPMC7226431
OpenAlexW3014835613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.