ArticleMicroorganisms2020
Relationships Between Gut Microbiota, Metabolome, Body Weight, and Glucose Homeostasis of Obese Dogs Fed with Diets Differing in Prebiotic and Protein Content.
Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Diet-induced metabolic and faecal microbiome responses in pet dogs fed a minimally processed versus extruded kibble diet.Frontiers in veterinary science · 2026Article
- Gut Metabolome in Companion Animal Nutrition-Linking Diets to Health.Animals : an open access journal from MDPI · 2025Review
- Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs.Scientific reports · 2024Article
- Decoding the Gut Microbiome in Companion Animals: Impacts and Innovations.Microorganisms · 2024Review
- Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes.Applied microbiology and biotechnology · 2024Article
- Faecal metabolome responses to an altered dietary protein:carbohydrate ratio in adult dogs.The veterinary quarterly · 2023Article
- Composition and evolution of the gut microbiota of growing puppies is impacted by their birth weight.Scientific reports · 2023Article
- Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition.iScience · 2023Article
- Different Diet Energy Levels Alter Body Condition, Glucolipid Metabolism, Fecal Microbiota and Metabolites in Adult Beagle Dogs.Metabolites · 2023Article
- Small molecule metabolites: discovery of biomarkers and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Enhancing immune response, antioxidant capacity, and gut health in growing beagles through a chitooligosaccharide diet.Frontiers in veterinary science · 2023Article
- Evaluation of the Influence of Coprophagic Behavior on the Digestibility of Dietary Nutrients and Fecal Fermentation Products in Adult Dogs.Veterinary sciences · 2022Article
- Characterization of intestinal microbiota in normal weight and overweight Border Collie and Labrador Retriever dogs.Scientific reports · 2022Article
- Article
- Catching a glimpse of the bacterial gut community of companion animals: a canine and feline perspective.Microbial biotechnology · 2020Review
- Effects of High-Fat Diet at Two Energetic Levels on Fecal Microbiota, Colonic Barrier, and Metabolic Parameters in Dogs.Frontiers in veterinary science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a major issue in pets and nutritional strategies need to be developed, like promoting greater protein and fiber intake. This study aimed to evaluate the effects of dietary protein levels and prebiotic supplementation on the glucose metabolism and relationships between the gut, microbiota, metabolome, and phenotype of obese dogs. Six obese Beagle dogs received a diet containing 25.6% or 36.9% crude protein, with or without 1% short-chain fructo-oligosaccharide (scFOS) or oligofructose (OF), in a Latin-square study design. Fecal and blood samples were collected for metabolite analysis, untargeted metabolomics, and 16S rRNA amplicon sequencing. A multi-block analysis was performed to build a correlation network to identify relationships between fecal microbiota, metabolome, and phenotypic variables. Diets did not affect energy homeostasis, but scFOS supplementation modulated fecal microbiota composition and induced significant changes of the fecal metabolome. Bile acids and several amino acids were related to glucose homeostasis while specific bacteria gathered in metavariables had a high number of links with phenotypic and metabolomic parameters. It also suggested that fecal aminoadipate and hippurate act as potential markers of glucose homeostasis. This preliminary study provides new insights into the relationships between the gut microbiota, the metabolome, and several phenotypic markers involved in obesity and associated metabolic dysfunctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.