Evidence map›Paper›PMID 32260146›Full record

ReviewMolecules (Basel, Switzerland)2020

Chemistry, Biological Activities and In Silico Bioprospection of Sterols and Triterpenes from Mexican Columnar Cactaceae.

Juan Rodrigo Salazar, Marco A Loza-Mejía, Diego Soto-Cabrera

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  3. Phytochemical Insights and Therapeutic Potential ofMolecules (Basel, Switzerland) · 2025
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  4. Review
  5. Article
  6. First Evidence of Gastroprotection byMolecules (Basel, Switzerland) · 2022
    Article
  7. A Review of theMolecules (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Juan Rodrigo SalazarDesign, Isolation, and Synthesis of Bioactive Molecules Research Group, Chemical Sciences Faculty, Universidad La Salle. Benjamín Franklin 45, Mexico City 06140, Mexico.ORCID 0000-0002-8839-5849
Marco A Loza-MejíaDesign, Isolation, and Synthesis of Bioactive Molecules Research Group, Chemical Sciences Faculty, Universidad La Salle. Benjamín Franklin 45, Mexico City 06140, Mexico.
Diego Soto-CabreraDesign, Isolation, and Synthesis of Bioactive Molecules Research Group, Chemical Sciences Faculty, Universidad La Salle. Benjamín Franklin 45, Mexico City 06140, Mexico.ORCID 0000-0001-8023-0006
Universidad La Salle · MX

Funding

Universidad La Salle SAL-13/17
6 · The paper itself

Abstract

The Cactaceae family is an important source of triterpenes and sterols. The wide uses of those plants include food, gathering, medicinal, and live fences. Several studies have led to the isolation and characterization of many bioactive compounds. This review is focused on the chemistry and biological properties of sterols and triterpenes isolated mainly from some species with columnar and arborescent growth forms of Mexican Cactaceae. Regarding the biological properties of those compounds, apart from a few cases, their molecular mechanisms displayed are not still fully understand. To contribute to the above, computational chemistry tools have given a boost to traditional methods used in natural products research, allowing a more comprehensive exploration of chemistry and biological activities of isolated compounds and extracts. From this information an in silico bioprospection was carried out. The results suggest that sterols and triterpenoids present in Cactaceae have interesting substitution patterns that allow them to interact with some bio targets related to inflammation, metabolic diseases, and neurodegenerative processes. Thus, they should be considered as attractive leads for the development of drugs for the management of chronic degenerative diseases.

Indexed as

Anti-Inflammatory AgentsCactaceaeComputational ChemistryComputer SimulationHypoglycemic AgentsPlant ExtractsSterolsTriterpenesAnti-Inflammatory AgentsHypoglycemic AgentsPlant ExtractsSterolsTriterpenesbioactivitybioprospectionCactaceaediabetesinflammationin silico screeningsteroltriterpene

Identifiers

PMID32260146
PMCPMC7180492
OpenAlexW3014545666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.