Evidence map›Paper›PMID 32259702›Full record

ArticleInternational immunopharmacology2020

NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease.

Hayate Javed, Ramasamy Thangavel, Govindhasamy Pushpavathi Selvakumar, Iuliia Dubova, Noah Schwartz, Mohammad Ejaz Ahmed, Smita Zaheer, Duraisamy Kempuraj, Shankar Iyer, Asgar Zaheer and 1 more

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In one paragraph

Article in International immunopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  10. Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
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  19. Inflammasome Activation in Parkinson's Disease.Journal of Parkinson's disease · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Hayate JavedDepartment of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Anatomy, College of Medicine and Health Science, United Arab Emirates University, Al Ain, PO Box 17666, United Arab Emirates.
Ramasamy ThangavelDepartment of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.
Govindhasamy Pushpavathi SelvakumarDepartment of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.
Iuliia DubovaDepartment of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.
Noah SchwartzDepartment of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA.
Mohammad Ejaz AhmedDepartment of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.
Smita ZaheerDepartment of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.
Duraisamy KempurajDepartment of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.
Shankar IyerDepartment of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA.
Asgar ZaheerDepartment of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO 65201, USA; Veterans Affairs Health Care System, Iowa City, IA 52242, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201, USA. Electronic address: zaheera@health.missouri.edu.
Mohammad Moshahid KhanDepartment of Neurology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA; Department of Neurology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Division of Rehabilitation Sciences and Department of Physical Therapy, College of Health Professions, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: mkhan26@uthsc.edu.
University of Missouri · USUniversity of Iowa Hospitals and Clinics · USIowa City VA Health Care System · USUniversity of Tennessee Health Science Center · US

Funding

Therapeutic potential of GMF suppresssion in inflammation and neurodegenerationR01AG048205 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAHEER, ASGAR · 2015 to 2019
$1.6M
Glia maturation factor dependent mast cell activation in Parkinson's diseaseI01BX002477 · VA · IOWA CITY VA MEDICAL CENTER · PI ZAHEER, ASGAR · 2015 to 2017
–
BLRD VA I01 BX002477NIA NIH HHS R01 AG048205
6 · The paper itself

Abstract

Neuroinflammation plays an active role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD). Earlier studies from this laboratory showed that glia maturation factor (GMF), a proinflammatory mediator; is up-regulated in the brain in neurodegenerative diseases and that deficiency of GMF showed decreased production of IL-1β and improved behavioral abnormalities in mouse model of PD. However, the mechanisms linking GMF and dopaminergic neuronal death have not been completely explored. In the present study, we have investigated the expression of NLRP3 inflammasome and caspase-1 in the substantia nigra (SN) of human PD and non-PD brains by immunohistochemistry. Wild-type (WT) and GMF

Indexed as

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsApoptosisCells, CulturedDisease Models, AnimalDopaminergic NeuronsGlia Maturation FactorHumansInflammasomesMiceMice, KnockoutNeurogenic InflammationNeurogliaNLR Family, Pyrin Domain-Containing 3 ProteinParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineGlia Maturation FactorInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinGMFMPTPNLRP3 inflammasomeParkinson’s disease

Identifiers

PMID32259702
PMCPMC7255416
OpenAlexW3015009329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.