ArticleJournal of neuroscience methods2020
Focal transcranial magnetic stimulation in awake rats: Enhanced glucose uptake in deep cortical layers.
Article in Journal of neuroscience methods, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Effects of transcranial magnetic stimulation on spatial memory: a systematic review across animal and human studies.Frontiers in behavioral neuroscience · 2026Pooled it
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- Repetitive transcranial magnetic stimulation elicits weight loss and improved insulin sensitivity in type 2 diabetic rats.Animal models and experimental medicine · 2025Article
- A cell type-specific mechanism driving the rapid antidepressant effects of transcranial magnetic stimulation.bioRxiv : the preprint server for biology · 2025Article
- TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis.Journal of neuroinflammation · 2025Article
- Functional MRI reveals regional changes of brain activity in rats following longitudinal focal high-density theta burst stimulation (hdTBS).Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A 3D-Printed helmet for precise and repeatable neuromodulation targeting in awake non-human primates.Heliyon · 2024Article
- Ultra-high frequency repetitive TMS at subthreshold intensity induces suprathreshold motor response via temporal summation.Journal of neural engineering · 2024Article
- High inductance magnetic-core coils have enhanced efficiency in inducing suprathreshold motor response in rats.Physics in medicine and biology · 2023Article
- Consensus guidelines on the construct validity of rodent models of restless legs syndrome.Disease models & mechanisms · 2022Article
- Angle-tuned coils: attractive building blocks for TMS with improved depth-spread performance.Journal of neural engineering · 2022Article
- Anesthesia inhibited corticospinal excitability and attenuated the modulation of repetitive transcranial magnetic stimulation.BMC anesthesiology · 2022Article
- Treating cocaine and opioid use disorder with transcranial magnetic stimulation: A path forward.Pharmacology, biochemistry, and behavior · 2021Review
- Moving back in the brain to drive the field forward: Targeting neurostimulation to different brain regions in animal models of depression and neurodegeneration.Journal of neuroscience methods · 2021Article
- Transcranial Magnetic Stimulation as an Interventional Tool for Addiction.Frontiers in neuroscience · 2020Article
- A high-density theta burst paradigm enhances the aftereffects of transcranial magnetic stimulation: Evidence from focal stimulation of rat motor cortex.Brain stimulationArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTranscranial magnetic stimulation (TMS) is an emerging neuromodulation tool. However, preclinical models of TMS are limited.
objectiveTo develop a method for performing TMS in awake rats and to characterize neuronal response to TMS by mapping glucose uptake following TMS administration.
methodsA headpost was implanted into rat skull serving as a refence to guide TMS target. Motor threshold measurement was used as the metric to assess the consistency in TMS delivery across animals and across sessions. Using a fluorescent glucose analogue (2-NBDG) as a marker of neuronal activity, we mapped glucose uptake in response to TMS of the rat motor cortex.
resultsThe average motor threshold (n = 41) was 34.6 ± 6.3 % of maximum stimulator output (MSO). The variability of motor threshold across animals was similar to what has been reported in human studies. Furthermore, there was no significant difference in motor threshold measured across 3 separate days. Enhancement in fluorescent signals were TMS dose (power)-dependent, which centered around the motor cortex, covering an area medial-laterally 2 mm, rostral-caudally 4 mm at 55 % MSO, and 3 mm at 35 % MSO. The count of total cells with significant fluorescent signal was: 107 ± 23 (55 % MSO), 73 ± 11 (35 % MSO) and 42 ± 11 (sham, 5% MSO).
conclusionsOur method allows for consistent motor threshold assessment for longitudinal studies. Notably, cells with fluorescent signal enhancement were consistently aggregated in deep cortical layers, with minimal enhancement in superficial layers COMPARISONS WITH EXISTING METHOD(S): To our knowledge, this is the first study of focal TMS in awake rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.