ArticleNeuropsychologia2020
The role of the pre-commissural fornix in episodic autobiographical memory and simulation.
Article in Neuropsychologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 29 citations in OpenAlex.
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- Multimodal population study reveals the neurobiological underpinnings of chronotype.Nature human behaviour · 2025Article
- Concurrent representations of reinstated and transformed memories and their modulation by reward.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Brain-behavior correlates of rhythmic timing and auditory-motor synchronization in children with developmental coordination disorder: an EEG study.Frontiers in human neuroscience · 2025Article
- Brain connectivity patterns associated with individual differences in the access to experience-near personal semantics: a resting-state fMRI study.Cognitive, affective & behavioral neuroscience · 2024Article
- The fornix supports episodic memory during childhood.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The anterior thalamic nuclei: core components of a tripartite episodic memory system.Nature reviews. Neuroscience · 2022Review
- Individual differences in the relationship between episodic detail generation and resting state functional connectivity vary with age.Neuropsychologia · 2022Article
- Loneliness is linked to specific subregional alterations in hippocampus-default network covariation.Journal of neurophysiology · 2021Article
- Evolution, Emotion, and Episodic Engagement.The American journal of psychiatry · 2021Review
- The role of the medial prefrontal cortex in cognition, ageing and dementia.Brain communications · 2021Review
- The default network of the human brain is associated with perceived social isolation.Nature communications · 2020Article
- Brain structure correlates of expected social threat and reward.Scientific reports · 2020Article
- vmPFC Drives Hippocampal Processing during Autobiographical Memory Recall Regardless of Remoteness.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The relationship between hippocampal-dependent task performance and hippocampal grey matter myelination and iron content.Brain and neuroscience advancesArticle
- Impaired episodic simulation in a patient with visual memory deficit amnesia.Brain and neuroscience advancesArticle
- Precommissural and postcommissural fornix microstructure in healthy aging and cognition.Brain and neuroscience advancesArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuropsychological and functional magnetic resonance imaging evidence suggests that the ability to vividly remember our personal past, and imagine future scenarios, involves two closely connected regions: the hippocampus and ventromedial prefrontal cortex (vmPFC). Despite evidence of a direct anatomical connection from hippocampus to vmPFC, it is unknown whether hippocampal-vmPFC structural connectivity supports both past- and future-oriented episodic thinking. To address this, we applied a novel deterministic tractography protocol to diffusion-weighted magnetic resonance imaging (dMRI) data from a group of healthy young adult humans who undertook an adapted past-future autobiographical interview (portions of this data were published in Hodgetts et al., 2017a). This tractography protocol enabled distinct subdivisions of the fornix, detected previously in axonal tracer studies, to be reconstructed in vivo, namely the pre-commissural (connecting the hippocampus to vmPFC) and post-commissural (linking the hippocampus and medial diencephalon) fornix. As predicted, we found that inter-individual differences in pre-commissural - but not post-commissural - fornix microstructure (fractional anisotropy) were significantly correlated with the episodic richness of both past and future autobiographical narratives. Notably, these results held when controlling for non-episodic narrative content, verbal fluency, and grey matter volumes of the hippocampus and vmPFC. This study provides novel evidence that reconstructing events from one's personal past, and constructing possible future events, involves a distinct, structurally-instantiated hippocampal-vmPFC pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.