Evidence map›Paper›PMID 32259445›Full record

ArticleBiochemistry2020

Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1.

Amit Kumar, P Ross Wilderman, Chengjian Tu, Shichen Shen, Jun Qu, D Fernando Estrada

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amit KumarDepartment of Biochemistry, Jacobs School of Medicine, University at Buffalo, 955 Main Street, Buffalo, New York 14203, United States.
P Ross WildermanDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Storrs, Connecticut 06269, United States.
Chengjian TuDepartment of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, 318 Pharmacy Building, Buffalo, New York 14214, United States.
Shichen ShenDepartment of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, 318 Pharmacy Building, Buffalo, New York 14214, United States.
Jun QuDepartment of Pharmaceutical Sciences, School of Pharmacy, University at Buffalo, 318 Pharmacy Building, Buffalo, New York 14214, United States.ORCID 0000-0002-1346-6809
D Fernando EstradaDepartment of Biochemistry, Jacobs School of Medicine, University at Buffalo, 955 Main Street, Buffalo, New York 14203, United States.ORCID 0000-0002-7956-7610
University at Buffalo, State University of New York · USUniversity of Connecticut · US

Funding

Structural regulation of Class-I and Class-II cytochrome P450 enzymesR35GM133375 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI David Fernando Estrada · 2019 to 2026
$3.0M
Crystallographic and NMR studies of the Human Cytochrome P450 enzyme responsible for inactivating vitamin DR00GM112862 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ESTRADA, DAVID FERNANDO · 2016 to 2018
$747k
NIGMS NIH HHS R00 GM112862NIGMS NIH HHS R35 GM133375
6 · The paper itself

Abstract

Metabolic inactivation of 1,25(OH)

Indexed as

AdrenodoxinAllosteric RegulationBinding SitesHumansModels, MolecularSubstrate SpecificityVitamin D3 24-HydroxylaseAdrenodoxinCYP24A1 protein, humanVitamin D3 24-Hydroxylase

Identifiers

PMID32259445
PMCPMC7233526
OpenAlexW3014169304

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.