ArticleNeurosurgery2020
Case Series: Unilateral Amygdala Ablation Ameliorates Post-Traumatic Stress Disorder Symptoms and Biomarkers.
Article in Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Personalized fMRI-Guided TMS Targeting the Threat Neurocircuitry in PTSD: A Randomized Clinical Trial.The American journal of psychiatry · 2026Trial
- Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.Neurorehabilitation and neural repair · 2026Review
- Right amygdala ablation reduces maladaptive negative interpretation bias and symptoms in a patient with post-traumatic stress disorder.Nature communications · 2026Article
- Toward a definition of treatment-resistant posttraumatic stress disorder: A systematic review.Journal of military, veteran and family health · 2026Review
- Target variability and stability of neuroimaging-guided transcranial magnetic stimulation of the amygdala circuitry for posttraumatic stress disorder.Research square · 2026Article
- Impact of Post-Traumatic Stress Disorder Duration on Volumetric and Microstructural Parameters of the Hippo-Campus, Amygdala, and Prefrontal Cortex: A Multiparametric Magnetic Resonance Imaging Study with Correlation Analysis.Journal of clinical medicine · 2025Article
- Beta bursts mediate amygdala gating of hippocampal emotional encoding.bioRxiv : the preprint server for biology · 2025Article
- Fear perception as a function of hemisphere- and time-specific dynamics in the medial temporal lobes.Communications biology · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans.Nature neuroscience · 2024Article
- Article
- Deep brain stimulation of the amygdala for treatment-resistant combat post-traumatic stress disorder: Long-term results.Journal of psychiatric research · 2024Article
- A potential neuromodulation target for PTSD in Veterans derived from focal brain lesions.Research square · 2024Article
- Discovering how the amygdala shapes human behavior: From lesion studies to neuromodulation.Neuron · 2023Article
- Psychiatric changes after stereotactic laser amygdalohippocampotomy for medial temporal lobe epilepsy.Epilepsy & behavior : E&B · 2023Article
- Unilateral amygdala ablation: a potential treatment option for severe chronic post-traumatic stress disorder (PTSD)?Expert review of neurotherapeutics · 2023Article
- A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder.Nature communications · 2023Article
- Amygdala lesions are associated with improved mood after epilepsy surgery.Brain structure & function · 2023Article
- The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder.Frontiers in neuroscience · 2023Review
- Review
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12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPost-traumatic stress disorder is a severe psychobiological disorder associated with hyperactivity of the amygdala, particularly on the right side. Highly selective laser ablation of the amygdalohippocampal complex is an effective neurosurgical treatment for medically refractory medial temporal lobe epilepsy that minimizes neurocognitive deficits relative to traditional open surgery.
objectiveTo examine the impact of amygdalohippocampotomy upon symptoms and biomarkers of post-traumatic stress disorder.
methodsTwo patients with well-documented chronic post-traumatic stress disorder who subsequently developed late-onset epilepsy underwent unilateral laser amygdalohippocampotomy. Prospective clinical and neuropsychological measurements were collected in patient 1. Additional prospective measurements of symptoms and biomarkers were collected pre- and post-surgery in patient 2.
resultsAfter laser ablation targeting the nondominant (right) amygdala, both patients experienced not only reduced seizures, but also profoundly abated post-traumatic stress symptoms. Prospective evaluation of biomarkers in patient 2 showed robust improvements in hyperarousal symptoms, fear potentiation of the startle reflex, brain functional magnetic resonance imaging responses to fear-inducing stimuli, and emotional declarative memory.
conclusionThese observations support the emerging hypothesis that the right amygdala particularly perpetuates the signs and symptoms of post-traumatic stress disorder and suggests that focal unilateral amydalohippocampotomy can provide therapeutic benefit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.