ArticleCurrent developments in nutrition2020
Both Dietary Ratio of n-6 to n-3 Fatty Acids and Total Dietary Lipid Are Positively Associated with Adiposity and Reproductive Health in Zebrafish.
Article in Current developments in nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Nutrient Intake through Childhood and Early Menarche Onset in Girls: Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Genetic Structure and Genome-Wide Association Analysis of Growth and Reproductive Traits in Fengjing Pigs.Animals : an open access journal from MDPI · 2024Article
- Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment.bioRxiv : the preprint server for biology · 2024Article
- Disentangling the link between zebrafish diet, gut microbiome succession, and Mycobacterium chelonae infection.Animal microbiome · 2023Article
- Body Metrics and the Gut Microbiome in Response to Macronutrient Limitation in the ZebrafishCurrent developments in nutrition · 2023Article
- Common laboratory diets differentially influence zebrafish gut microbiome's successional development and sensitivity to pathogen exposure.Research square · 2023Article
- Article
- The effects of intensive feeding on reproductive performance in laboratory zebrafish (Danio rerio).PloS one · 2022Article
- Standardized Reference Diets for Zebrafish: Addressing Nutritional Control in Experimental Methodology.Annual review of nutrition · 2021Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundControversial findings have been reported in human and animal studies regarding the influence of n-6 (ω-6) to n-3 (ω-3) fatty acid ratios on obesity and health. Two confounding factors may be related to interactions with other dietary lipid components or sex-specific differences in fatty acid metabolism.
objectiveThis study investigated main and interactive effects of total dietary lipid, ratio of n-6 to n-3 fatty acids, and sex on growth, adiposity, and reproductive health in wild-type zebrafish.
methodsMale and female zebrafish (3 wk old) were fed 9 diets consisting of 3 ratios of n-6 to n-3 fatty acids (1.4:1, 5:1, and 9.5:1) varied within 3 total lipid amounts (80, 110, and 140 g/kg) for 16 wk. Data were then collected on growth, body composition (determined by chemical carcass analysis), and female reproductive success (
resultsDietary lipid and sex interacted in their effects on body weight (
conclusionsFurther characterization of dietary lipid requirements will help define healthy balances of dietary lipid, while the sex-specific responses to dietary lipid identified in this study may partially explain sex disparities in the development of obesity and its comorbidities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.