Evidence map›Paper›PMID 32258496›Full record

ArticleHeliyon2020

Herpes simplex encephalitis: A new type of "ICU-acquired infection"?

Fabien Hauw, Vera Dinkelacker, Pierre Jaquet, Hervé Vespignani, Charles Grégoire, Mathilde Perrin, Nicolas Engrand

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Fabien HauwNeuro-Intensive Care Unit, Fondation Rothschild, 29 rue Manin, 75019 Paris, France.
Vera DinkelackerDepartment of Neurology, Fondation Rothschild, 29 rue Manin, 75019 Paris, France.
Pierre JaquetIntensive Care Unit, Department of Neurology, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris 47-85 Bd de l'Hôpital 75013 Paris, France.
Hervé VespignaniSerenity Medical Services - NeuroPhy, ICM-iPEPS, 47-85 Bd de l'Hôpital, 75013 Paris, France1http://www.serenitymedicalservices.com.
Charles GrégoireNeuro-Intensive Care Unit, Fondation Rothschild, 29 rue Manin, 75019 Paris, France.
Mathilde PerrinNeuro-Intensive Care Unit, Fondation Rothschild, 29 rue Manin, 75019 Paris, France.
Nicolas EngrandNeuro-Intensive Care Unit, Fondation Rothschild, 29 rue Manin, 75019 Paris, France.
Fondation de Rothschild · FRPitié-Salpêtrière Hospital · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough it is a well-known disease, the occurrence of MATERIALS AND

methodsClinical observation of one patient. CASE REPORT: An 87-year-old male was admitted to the Intensive Care Unit (ICU) because of respiratory failure due to an exacerbation of myasthenia gravis. After corticoids and azathioprine treatment, his clinical condition improved, allowing weaning from mechanical ventilation. One month after admission, while still hospitalized in the ICU, the patient developed fever and confusion. In the context of confounding factors, HSE was not suspected before a convulsive status epilepticus occurred, resulting in a significant delay in treatment. Diagnosis was confirmed by PCR-analysis in the cerebrospinal fluid. Serological status confirmed reactivation of prior herpes simplex infection. The patient died one week after the onset of confusion.

conclusionsHospital-"acquired" HSE must be suspected in case of new neurologic symptoms associated with fever, even in ICU-hospitalized patients. The diagnosis is made even more difficult by nonspecific symptoms due to previous diseases, leading to an even more severe prognosis in those vulnerable patients.

Indexed as

ElectrophysiologyHerpes simplex EncephalitisHerpes simplex reactivationICU acquired InfectionImmunosuppressionInfectious diseaseIntensive careIntensive care medicineNeurologyNeurosurgery

Identifiers

PMID32258496
PMCPMC7113434
OpenAlexW3013333792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.