Evidence map›Paper›PMID 32258437›Full record

ArticleJournal of clinical tuberculosis and other mycobacterial diseases2020

Burden of tuberculosis and challenges related to screening and diagnosis in Ethiopia.

Hussen Mohammed, Lemessa Oljira, Kedir Teji Roba, Esther Ngadaya, Tigest Ajeme, Tewodros Haile, Achenef Kidane, Tsegahun Manyazewal, Abebaw Fekadu, Getnet Yimer

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Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Magnitude and trends ofThe Pan African medical journal · 2025
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  11. Development and validation of the Tuberculosis Diabetes Mellitus-Predictive Tool (TBDM-PT) in primary care.Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia · 2025
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  16. Cost-effectiveness of TB diagnostic technologies in Ethiopia: a modelling study.Cost effectiveness and resource allocation : C/E · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hussen MohammedDepartment of Public Health, College of Medicine and Health Sciences, Dire Dawa University, Dire Dawa, Ethiopia.
Lemessa OljiraSchool of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Kedir Teji RobaSchool of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.
Esther NgadayaMuhimbili Research Centre, National Institute for Medical Research, Dares Saalem, Tanzania.
Tigest AjemeCentre for Innovative Drug Development and Therapeutic Trials for Africa, College of Health Sciences, Addis Ababa University, P.O. Box 1362, Dire Dawa, Ethiopia.
Tewodros HaileDepartment of Internal Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Achenef KidaneCentre for Innovative Drug Development and Therapeutic Trials for Africa, College of Health Sciences, Addis Ababa University, P.O. Box 1362, Dire Dawa, Ethiopia.
Tsegahun ManyazewalCentre for Innovative Drug Development and Therapeutic Trials for Africa, College of Health Sciences, Addis Ababa University, P.O. Box 1362, Dire Dawa, Ethiopia.
Abebaw FekaduCentre for Innovative Drug Development and Therapeutic Trials for Africa, College of Health Sciences, Addis Ababa University, P.O. Box 1362, Dire Dawa, Ethiopia.
Getnet YimerCentre for Innovative Drug Development and Therapeutic Trials for Africa, College of Health Sciences, Addis Ababa University, P.O. Box 1362, Dire Dawa, Ethiopia.

Funding

Ethiopia-Emory TB Research Training ProgramD43TW009127 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Kidist Bobosha · 2013 to 2026
$3.4M
FIC NIH HHS D43 TW009127Medical Research Council MR/M025470/1
6 · The paper itself

Abstract

introductionOne-third of tuberculosis (TB) cases in Ethiopia are missing from care for reasons that are not well studied. The aim of this study was to assess TB burden and identify challenges related to TB screening and diagnosis in Ethiopia.

methodsA facility-based cross-sectional study was conducted in seven health facilities selected from two regions and 2 city administrations of Ethiopia using stratified random sampling procedures. The data of 1,059,065 patients were included from outpatient department, HIV clinic, diabetic, and maternal-child health clinics. Data were collected from October to December 2018 using a retrospective review of three years' facility data (2015 to 2017) supplemented by a semi-structured interview with purposively selected health care workers and heads of the health facilities.

resultsA total of 1,059,065 patients visited the health facilities in three years, of these, 978,480 (92.4%) were outpatients. Of the total, 20,284 (2%) were presumptive TB cases

conclusionThe burden of TB was high in the study setting, and frequent interruption of laboratory reagents and supplies hampered TB screening and diagnostic services. Realizing the END-TB strategy in such resource-limited settings requires sustainable TB diagnostic capacity and improved case detection mechanisms, with national TB programs strongly integrated into the general health care system.

Indexed as

AFB, acid fast bacilliANC, ant-natal careART, anti-retroviral therapy, DOTS, directly observed treatment, short courseDiagnosiseHMIS, electronic Health Management Information SystemEPTB, extra pulmonary tuberculosisEthiopiaFMoH, Federal Ministry of HealthHIV, human immunodeficiency virusMaternal and child healthMDR-TB, multi-drug resistant tuberculosisNGOs, non-governmental organizationsNTB, National TB programPFSA, Pharmaceutical Fund and Supply AgencyPMTCT, prevention mother to child transmissionPNC, postnatal careScreeningTB, tuberculosisTuberculosisWHO, World Health OrganizationXpert mtb/rif assay

Identifiers

PMID32258437
PMCPMC7113623

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.