Evidence map›Paper›PMID 32258414›Full record

ArticleOpen medicine (Warsaw, Poland)2020

Primary Cutaneous DLBCL Non-GCB Type: Challenges of a Rare Case.

Antonello Sica, Paola Vitiello, Stefano Caccavale, Caterina Sagnelli, Armando Calogero, Concetta Anna Doraro, Francesco Pastore, Fortunato Ciardiello, Giuseppe Argenziano, Alfonso Reginelli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Open medicine (Warsaw, Poland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Antonello SicaOncology and Hematology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Paola VitielloDermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Stefano CaccavaleDermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Caterina SagnelliDepartment of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli, Naples", Italy.
Armando CalogeroGeneral Surgery and Transplant Unit, Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
Concetta Anna DoraroGeneral Surgery and Transplant Unit, Department of Advanced Biomedical Sciences, University "Federico II", Naples, Italy.
Francesco PastoreRadiotherapy Unit, Emicenter, Casavatore (Naples), Italy.
Fortunato CiardielloOncology and Hematology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giuseppe ArgenzianoDermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Alfonso ReginelliSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples. Italy.
Salvatore CappabiancaSection of Radiology and Radiotherapy, Department of Precision Medicine, University of Campania "L. Vanvitelli", Naples. Italy.
Renato FrancoPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Andrea RonchiPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITFederico II University Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell lymphomas does not include diffuse large B-cell lymphomas (DLBCL) and considers leg-type DLBCL the only primary cutaneous DLBCL. Here we report the case of a 72-year-old white woman with a primary cutaneous neoplasm comprised of large cells with round nuclei, irregularly clumped chromatin and one or more inconspicuous nucleoli. The immunohistochemistry demonstrated positivity for CD20 and MUM1, with no significant genetic translocations detected by fluorescence in-situ hybridization. After staging, we considered this neoplasm a primary cutaneous DLBCL with a non-germinal center phenotype, not otherwise specified, inconsistent with a leg-type DLBCL. Because of this view, we underscore the need for greater knowledge of the molecular landscape of B-cell lymphomas in order to reconsider the classification of such neoplasms in the skin.

Indexed as

B-cell lymphomaCutaneous lymphomaDiffuse large B cell lymphomaFISHLeg-type lymphoma

Identifiers

PMID32258414
PMCPMC7101477
OpenAlexW3011087134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.