Evidence map›Paper›PMID 32258397›Full record

ArticleScience advances2020

Three dimensions, two microscopes, one code: Automatic differentiation for x-ray nanotomography beyond the depth of focus limit.

Ming Du, Youssef S G Nashed, Saugat Kandel, Doğa Gürsoy, Chris Jacobsen

Abstract read
In one paragraph

Article in Science advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Upscaling X-ray nanoimaging to macroscopic specimens.Journal of applied crystallography · 2021
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ming DuDepartment of Materials Science, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-1602-6646
Youssef S G NashedMathematics and Computer Science Division, Argonne National Laboratory, Lemont, IL 60439, USA.ORCID 0000-0001-6146-3939
Saugat KandelApplied Physics Program, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-7324-2559
Doğa GürsoyAdvanced Photon Source, Argonne National Laboratory, Lemont, IL 60439, USA.ORCID 0000-0002-0080-8101
Chris JacobsenAdvanced Photon Source, Argonne National Laboratory, Lemont, IL 60439, USA.ORCID 0000-0001-8562-0353

Funding

Cryo ptychography combined with x-ray fluorescence analysis of metals in cellsR01GM104530 · NIGMS · NORTHWESTERN UNIVERSITY · PI JACOBSEN, CHRIS JOHNSON · 2013 to 2020
$2.2M
Development of Sub 100 nm Resolution X-ray Nanotomography of Centimeter-Sized TissuesR01MH115265 · NIMH · NORTHWESTERN UNIVERSITY · PI JACOBSEN, CHRIS JOHNSON · 2018 to 2021
$1.5M
NIGMS NIH HHS R01 GM104530NIMH NIH HHS R01 MH115265
6 · The paper itself

Abstract

Conventional tomographic reconstruction algorithms assume that one has obtained pure projection images, involving no within-specimen diffraction effects nor multiple scattering. Advances in x-ray nanotomography are leading toward the violation of these assumptions, by combining the high penetration power of x-rays, which enables thick specimens to be imaged, with improved spatial resolution that decreases the depth of focus of the imaging system. We describe a reconstruction method where multiple scattering and diffraction effects in thick samples are modeled by multislice propagation and the 3D object function is retrieved through iterative optimization. We show that the same proposed method works for both full-field microscopy and for coherent scanning techniques like ptychography. Our implementation uses the optimization toolbox and the automatic differentiation capability of the open-source deep learning package TensorFlow, demonstrating a straightforward way to solve optimization problems in computational imaging with flexibility and portability.

Identifiers

PMID32258397
PMCPMC7101216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.