ArticleRegenerative engineering and translational medicine2020
A 30% Volumetric Muscle Loss Does Not Result in Sustained Functional Deficits after a 90-Day Recovery in Rats.
Article in Regenerative engineering and translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cellular signaling within aged skeletal muscle reveals a dysregulated stress-induced remodeling response following volumetric muscle loss in female mice.Physiological reports · 2026Article
- Extracellular Matrix-Mediated Crosslinking of Adhesive Hyaluronic Acid Patch for Treating Volumetric Muscle Injury.Advanced healthcare materials · 2025Article
- Freeze-Dried Porous Collagen Scaffolds for the Repair of Volumetric Muscle Loss Injuries.ACS biomaterials science & engineering · 2025Article
- Freeze-dried porous collagen scaffolds for the repair of volumetric muscle loss injuries.bioRxiv : the preprint server for biology · 2024Article
- A critical size volumetric muscle loss model in mouse masseter with impaired mastication on nutrition.Cell proliferation · 2024Article
- Photoreactive Hydrogel Stiffness Influences Volumetric Muscle Loss Repair.Tissue engineering. Part A · 2022Article
- Cells, scaffolds, and bioactive factors: Engineering strategies for improving regeneration following volumetric muscle loss.Biomaterials · 2021Review
- Next Stage Approach to Tissue Engineering Skeletal Muscle.Bioengineering (Basel, Switzerland) · 2020Review
- Repairing Volumetric Muscle Loss in the Ovine Peroneus Tertius Following a 3-Month Recovery.Tissue engineering. Part A · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
Volumetric muscle loss (VML) is defined as the loss of skeletal muscle tissue which exceeds the body's repair capabilities leading to sustained functional deficits over time. Some etiologies leading to VML include traumatic injuries, congenital diseases, and degenerative myopathies. Currently, the lack of standardized animal models prevents an appropriate estimation of the severity of injury capable of exceeding self-regeneration. Recent work in our laboratory has shown that a 30% VML does not create a sustained functional loss in rats after 3 months. Therefore, the purpose of this study was to evaluate the percentage threshold of muscle loss that results in permanent functional deficits. We surgically created models of 30, 40, and 50% VML injuries in the tibialis anterior (TA) of rats, and subsequently evaluated TA function and structure after a 90-day recovery period. TA muscle force production was measured
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.