ArticleInternational journal of cardiology. Heart & vasculature2020
Clinical relationship between anemia and atrial fibrillation recurrence after catheter ablation without genetic background.
Article in International journal of cardiology. Heart & vasculature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- The association of hemoglobin with postoperative delirium and atrial fibrillation after cardiac surgery: a retrospective sub-study.Brazilian journal of anesthesiology (Elsevier)Trial
- Hemoglobin Levels as a Marker of Arrhythmia Recurrence After Atrial Fibrillation Ablation.Journal of arrhythmia · 2026Article
- Chronic but not Transient Anemia Is Associated With Atrial Fibrillation Recurrence After Catheter Ablation.Journal of arrhythmia · 2026Article
- Preserved Ejection, Lost Rhythm: A Narrative Review of the Pathophysiology and Management of Heart Failure with Preserved Ejection Fraction and Concomitant Atrial Fibrillation.Journal of clinical medicine · 2026Review
- Machine learning models of inflammatory markers used in the prediction of early and late atrial fibrillation recurrence in overweight and obese patients after catheter ablation.Cardiology journal · 2026Article
- Association between anemia and 1-year recurrence of paroxysmal atrial fibrillation after radiofrequency ablation.Journal of translational internal medicine · 2025Article
- Hematological parameters in atrial fibrillation: A literature review.World journal of cardiology · 2025Review
- Association of albuminuria with incident atrial fibrillation in healthy older adults.Clinical kidney journal · 2025Article
- Glutathione peroxidase 4 as a potential biomarker for atrial fibrosis and recurrence of atrial fibrillation.Heart rhythm O2 · 2025Article
- Freedom of Atrial Fibrillation Predictions After Pulmonary Vein Isolation: A Review of Current Evidence.Reviews in cardiovascular medicine · 2025Review
- Prediction model and scoring system for the risk of atrial fibrillation recurrence in patients with atrial fibrillation and obstructive sleep apnoea syndrome: a retrospective case-control study.BMC cardiovascular disorders · 2025Article
- Investigation of predictive parameters for recurrence in patients undergoing electrical cardioversion for atrial fibrillation.Journal of arrhythmia · 2025Article
- Advances in iron deficiency and iron-related arrhythmias and cardiovascular diseases.Frontiers in cardiovascular medicine · 2025Review
- Machine learning model for predicting late recurrence of atrial fibrillation after catheter ablation.Scientific reports · 2023Article
- A review of the impact, pathophysiology, and management of atrial fibrillation in patients with heart failure with preserved ejection fraction.American heart journal plus : cardiology research and practice · 2023Review
- Article
- Postpartum anemia and its determinant factors among postnatal women in two selected health institutes in Gondar, Northwest Ethiopia: A facility-based, cross-sectional study.Frontiers in medicine · 2023Article
- Anemia and iron deficiency in patients with atrial fibrillation.BMC cardiovascular disorders · 2022Review
- Sex-based Approach for the Clinical Impact of the Increased Hemoglobin on Incident AF in the General Population.Korean circulation journal · 2020Article
- Association of Atrial Fibrillation with Insomnia in the Elderly Population.Journal of primary care & community healthArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnemia is a known adverse prognostic factor among patients with cardiovascular diseases. We investigated whether the hemoglobin level was associated with the rhythm outcome after atrial fibrillation (AF) catheter ablation (AFCA).
methodsWe included 2627 patients who underwent AFCA and a guidelines-based rhythm follow-up (age 58 ± 10.9 years, 73% men, 30.6% with persistent AF), and evaluated the association of pre-AFCA anemia (haemoglobin <13 g/dL in men and <12 g/dL in women) and rhythm outcomes. We studied the mechanistic relationship between anemia and AF recurrence using a Mendelian randomization analysis (1775 subjects with genome-wide association study) after reviewing already proven 12 hemoglobin-associated genetic polymorphisms.
resultsThe body mass index, paroxysmal AF, warfarin use, and baseline red cell distribution width were independently associated with anemia in patients with AF. During a 23-month follow-up (interval OR 9-48 months), the clinical AF recurrence rate was significantly higher in patients with than without anemia (log-rank p = 0.001; propensity score-matched log-rank p = 0.004). This pattern was more significant in male patients (Log-rank p < 0.001) or patients with paroxysmal AF (Log-rank p < 0.001). Anemia (hazard ratio [HR] 1.45 [1.17-1.80], p = 0.001), left atrial diameter (HR 1.03 [1.01-1.04], p < 0.001), a female sex (HR 1.17 [1.00-1.36], p = 0.047), and persistent AF (HR 1.58 [1.36-1.84], p < 0.001) were independently associated with post-AFCA clinical recurrence. In the Mendelian randomization, we could not find a significant direct causal relationship between anemia and AF recurrence at the genetic level.
conclusionsPre-AFCA anemia is an independent predictor of post-AFCA clinical recurrence, especially in male patients, without a genetically direct causal relationship.
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