Evidence map›Paper›PMID 32258258›Full record

ArticleNeurobiology of stress2020

Towards a psychobiotic therapy for depression:

Peijun Tian, Kenneth J O'Riordan, Yuan-Kun Lee, Gang Wang, Jianxin Zhao, Hao Zhang, John F Cryan, Wei Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 6 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 6 syntheses or guidelines pooled it, 285 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Probiotics for the treatment of depression and its comorbidities: A systemic review.Frontiers in cellular and infection microbiology · 2023
    Pooled it
  6. Pooled it
  7. Nutrients · 2023
    Trial
  8. Trial
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Smart CaCOScientific reports · 2026
    Article
  15. Article
  16. Review
  17. Review
  18. Regulating the crosstalk betweenFrontiers in immunology · 2026
    Review
  19. Review
  20. Review

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Peijun TianState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
Kenneth J O'RiordanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Yuan-Kun LeeDepartment of Microbiology & Immunology, National University of Singapore, Singapore, 117597, Singapore.
Gang WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
Jianxin ZhaoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
Hao ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
State Key Laboratory of Food Science and Technology · CNUniversity College Cork · IEYangzhou University · CNJiangnan University · CNNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating evidence points to an association between gut microbial abnormalities and depression disorder. The microbiota-gut-brain axis is an emerging target for treating depression using nutritional strategies, considering the numerous limitations of current pharmacological approaches. Here we studied the effect and probable mechanisms of psychobiotic treatment on depression.

methodsChronically stressed C57BL/6J male mice were administered viable

resultsCCFM1025 treatment significantly reduced depression- and anxiety-like behaviors. The hyperactive hypothalamic-pituitary-adrenal response, as well as inflammation, were also alleviated, possibly via regulating the expression of glucocorticoid receptors (

conclusionsIn summary,

Indexed as

5-HydroxytryptophanBifidobacteriumDepressionPsychobioticsStress

Identifiers

PMID32258258
PMCPMC7109524
OpenAlexW3011145390

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.