ArticleNeurobiology of stress2020
Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects.
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Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Emotional Disorders, Risk Factors, and Correlations of Post-Partum Depression and Post-Traumatic Stress Disorder with Sexual Function During Post-Partum Period.Diagnostics (Basel, Switzerland) · 2025Article
- HIV-1 Tat Impairment of Mitochondrial Respiration via Complexes I and II Can Be Ameliorated by Allopregnanolone in Opioid-Exposed or Opioid-Naïve Cells and Mice.Antioxidants (Basel, Switzerland) · 2025Article
- Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation.Communications biology · 2024Article
- HIV-1 Tat and morphine interactions dynamically shift striatal monoamine levels and exploratory behaviors over time.Journal of neurochemistry · 2024Article
- Impaired extinction of cocaine seeking in HIV-infected mice is accompanied by peripheral and central immune dysregulation.Research square · 2023Article
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- HIV-1 Tat reduces apical dendritic spine density throughout the trisynaptic pathway in the hippocampus of male transgenic mice.Neuroscience letters · 2022Article
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- Allopregnanolone and neuroHIV: Potential benefits of neuroendocrine modulation in the era of antiretroviral therapy.Journal of neuroendocrinology · 2022Review
- Neurodegeneration Within the Amygdala Is Differentially Induced by Opioid and HIV-1 Tat Exposure.Frontiers in neuroscience · 2022Article
- In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain.GeroScience · 2021Article
- Red Algal Sulfated Galactan Binds and Protects Neural Cells from HIV-1 gp120 and Tat.Pharmaceuticals (Basel, Switzerland) · 2021Article
- HIV-1 Tat and morphine decrease murine inter-male social interactions and associated oxytocin levels in the prefrontal cortex, amygdala, and hypothalamic paraventricular nucleus.Hormones and behavior · 2021Article
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- HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status.GeroScience · 2021Article
- Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- HIV-1 Tat Dysregulates the Hypothalamic-Pituitary-Adrenal Stress Axis and Potentiates Oxycodone-Mediated Psychomotor and Anxiety-Like Behavior of Male Mice.International journal of molecular sciences · 2020Article
- Allopregnanolone (1938-2019): A trajectory of 80 years of outstanding scientific achievements.Neurobiology of stress · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Jason J ParisDepartment of BioMolecular Sciences, University of Mississippi, School of Pharmacy, University, MS, 38677-1848, USA.
Philippe LiereU1195 Inserm and University Paris-Sud and University Paris-Saclay, 94276, Le Kremlin-Bicêtre, France.
Sarah KimDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA, 23298, USA.
Fakhri MahdiDepartment of BioMolecular Sciences, University of Mississippi, School of Pharmacy, University, MS, 38677-1848, USA.
Meagan E BuchananDepartment of BioMolecular Sciences, University of Mississippi, School of Pharmacy, University, MS, 38677-1848, USA.
Sara R NassDepartment of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, VA, 23298, USA.
Alaa N QrareyaDepartment of BioMolecular Sciences, University of Mississippi, School of Pharmacy, University, MS, 38677-1848, USA.
Mohammed F SalahuddinDepartment of BioMolecular Sciences, University of Mississippi, School of Pharmacy, University, MS, 38677-1848, USA.
Antoine PianosU1195 Inserm and University Paris-Sud and University Paris-Saclay, 94276, Le Kremlin-Bicêtre, France.
Neïké FernandezU1195 Inserm and University Paris-Sud and University Paris-Saclay, 94276, Le Kremlin-Bicêtre, France.
Zia Shariat-MadarDepartment of BioMolecular Sciences, University of Mississippi, School of Pharmacy, University, MS, 38677-1848, USA.
Pamela E KnappDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA, 23298, USA.
Michael SchumacherU1195 Inserm and University Paris-Sud and University Paris-Saclay, 94276, Le Kremlin-Bicêtre, France.
Kurt F HauserDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA, 23298, USA.
University of Mississippi · USInserm · FRVirginia Commonwealth University · US
Funding
MOR and CCR5 interactive signaling mediates opiate and HIV-driven synaptodendritic injuryR01DA034231 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F, KNAPP, PAMELA E · 2013 to 2023
$5.4MPilot Project ProgramP30GM122733 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2018 to 2022
$5.3MMechanisms of Opiate Drug-HIV-Induced NeurodegenerationR01DA018633 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2005 to 2021
$4.4MGlial Progenitors as Targets of HIV/Opiate InteractionsR01DA024461 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KNAPP, PAMELA E · 2007 to 2018
$3.9MRegulation of HIV and opiate-directed synaptodendritic injury/death in striatumR01DA033200 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2013 to 2017
$2.1MSelective vulnerability of discrete neural circuits in the striatum to HIV-opiate comorbidityR01DA045588 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2018 to 2022
$2.0MNeuron-Glia Mechanisms & Interactions Underlying Opioid Abuse-HIV-1 ComorbidityK02DA027374 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F · 2009 to 2018
$1.3MOpiate abuse and sex steroids influence neuroAIDS pathologyR00DA039791 · NIDA · UNIVERSITY OF MISSISSIPPI · PI PARIS, JASON RICHARD · 2017 to 2019
$734kGlial CCR5 mediates HIV-Tat and opiate neurotoxicityF30DA044875 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KIM, SARAH · 2018 to 2018
$36kNIDA NIH HHS F30 DA044875NIDA NIH HHS K02 DA027374NIDA NIH HHS R00 DA039791NIDA NIH HHS R01 DA018633NIDA NIH HHS R01 DA024461NIDA NIH HHS R01 DA033200NIDA NIH HHS R01 DA034231NIDA NIH HHS R01 DA045588NIGMS NIH HHS P30 GM122733
Abstract
Pregnane steroids, particularly allopregnanolone (AlloP), are neuroprotective in response to central insult. While unexplored
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5α-pregnan-3α-ol-20-oneGlucocorticoid resistanceHIV/AIDSNeurosteroidOpioidStress
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.