Evidence map›Paper›PMID 32258255›Full record

ArticleNeurobiology of stress2020

Interactions between pyridostigmine bromide and stress on glutamatergic neurochemistry: Insights from a rat model of Gulf War Illness.

V A Macht, J L Woodruff, H E Burzynski, C A Grillo, L P Reagan, J R Fadel

Open access · goldAbstract read
In one paragraph

Article in Neurobiology of stress, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. A cellular approach to understanding and treating Gulf War Illness.Cellular and molecular life sciences : CMLS · 2021
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

V A MachtUniversity of South Carolina School of Medicine, Department of Pharmacology, Physiology, and Neuroscience, Columbia, SC, 29208, USA.
J L WoodruffUniversity of South Carolina School of Medicine, Department of Pharmacology, Physiology, and Neuroscience, Columbia, SC, 29208, USA.
H E BurzynskiUniversity of South Carolina School of Medicine, Department of Pharmacology, Physiology, and Neuroscience, Columbia, SC, 29208, USA.
C A GrilloUniversity of South Carolina School of Medicine, Department of Pharmacology, Physiology, and Neuroscience, Columbia, SC, 29208, USA.
L P ReaganUniversity of South Carolina School of Medicine, Department of Pharmacology, Physiology, and Neuroscience, Columbia, SC, 29208, USA.
J R FadelUniversity of South Carolina School of Medicine, Department of Pharmacology, Physiology, and Neuroscience, Columbia, SC, 29208, USA.
University of South Carolina · US

Funding

Decreased CNS leptin activity in co-morbid depression and obesityI01BX001804 · VA · VETERANS HEALTH ADMINISTRATION · PI REAGAN, LAWRENCE P · 2013 to 2021
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Immune basis for hippocampal cholinerginc deficits in pyridostigmine-treated ratsI01BX002664 · VA · VETERANS HEALTH ADMINISTRATION · PI LAWRENCE P REAGAN · 2015 to 2026
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BLRD VA I01 BX001804BLRD VA I01 BX002664
6 · The paper itself

Abstract

Pyridostigmine bromide (PB) was administered to soldiers during the first Gulf War as a prophylactic treatment to protect against toxicity in the event of exposure to nerve agents. Although originally thought to pose minimal risk to soldiers, epidemiological studies have since correlated PB administration with the development of a variety of symptoms, including cognitive dysfunction, termed Gulf War Illness (GWI). We previously demonstrated in a rodent model of GWI that central cholinergic responses were altered to various stimuli. In the current study we used

Indexed as

Acetylcholinesterasecholinesterase, ChEcorticosterone, CORTGulf War, GWGulf War Illness, GWIHippocampusLipopolysaccharidelipopolysaccharide, LPSMicrodialysisnon-stressed control, NSCPrefrontal cortexprefrontal cortex, PFCpyridostigmine bromide, PBrepeated restraint stress, RRS

Identifiers

PMID32258255
PMCPMC7109514
OpenAlexW2996940364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.